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528 Result(s)
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Article
Open AccessComparison and phylogenetic analysis of the mitochondrial genomes of Synodontis eupterus and Synodontis polli
We aimed to distinguish Synodontis eupterus and Synodontis polli. We performed sequencing and bioinformatic analysis of their mitochondrial genomes and constructed a phylogenetic tree of Mochokidae fish using max...
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Open AccessAuthor Correction: ALKBH5-mediated m6A modification of IL-11 drives macrophage-to-myofibroblast transition and pathological cardiac fibrosis in mice
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Open AccessDSnet: a new dual-branch network for hippocampus subfield segmentation
The hippocampus is a critical component of the brain and is associated with many neurological disorders. It can be further subdivided into several subfields, and accurate segmentation of these subfields is of ...
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Open AccessIdentification of a novel lactylation-related gene signature predicts the prognosis of multiple myeloma and experiment verification
Multiple myeloma (MM) is an incurable hematological malignancy with poor survival. Accumulating evidence reveals that lactylation modification plays a vital role in tumorigenesis. However, research on lactylat...
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Open AccessIFNγ-IL12 axis regulates intercellular crosstalk in metabolic dysfunction-associated steatotic liver disease
Obesity is a major cause of metabolic dysfunction-associated steatohepatitis (MASH) and is characterized by inflammation and insulin resistance. Interferon-γ (IFNγ) is a pro-inflammatory cytokine elevated in o...
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Open AccessKinetic nitrogen isotope effects of 18 amino acids degradation during burning processes
Understanding the nitrogen isotopic variations of individual amino acids (AAs) is essential for utilizing the nitrogen isotope values of individual amino acids (δ15N-AA) as source indicators to identify proteinac...
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Open AccessSimulating multiple variability in spatially resolved transcriptomics with scCube
A pressing challenge in spatially resolved transcriptomics (SRT) is to benchmark the computational methods. A widely-used approach involves utilizing simulated data. However, biases exist in terms of the curre...
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Open AccessOptimizing cell therapy by sorting cells with high extracellular vesicle secretion
Critical challenges remain in clinical translation of extracellular vesicle (EV)-based therapeutics due to the absence of methods to enrich cells with high EV secretion. Current cell sorting methods are limite...
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Open AccessPPIA dictates NRF2 stability to promote lung cancer progression
Nuclear factor erythroid 2-related factor 2 (NRF2) hyperactivation has been established as an oncogenic driver in a variety of human cancers, including non-small cell lung cancer (NSCLC). However, despite mass...
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Open AccessCarbon storage through China’s planted forest expansion
China’s extensive planted forests play a crucial role in carbon storage, vital for climate change mitigation. However, the complex spatiotemporal dynamics of China’s planted forest area and its carbon storage ...
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Open AccessA chain mediation model reveals the association between family sense of coherence and quality of life in caregivers of advanced cancer patients
Caregivers of advanced cancer patients face challenges impacting their quality of life (QoL). While evidence suggests that family sense of coherence (FSOC) can enhance individual psychological well-being and r...
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Open AccessFrequency comb generation via synchronous pumped χ(3) resonator on thin-film lithium niobate
Resonator-based optical frequency comb generation is an enabling technology for a myriad of applications ranging from communications to precision spectroscopy. These frequency combs can be generated in nonline...
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Open AccessFlash heating process for efficient meat preservation
Maintaining food safety and quality is critical for public health and food security. Conventional food preservation methods, such as pasteurization and dehydration, often change the overall organoleptic qualit...
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Open AccessMap** annual 10-m soybean cropland with spatiotemporal sample migration
China, as the world’s biggest soybean importer and fourth-largest producer, needs accurate map** of its planting areas for global food supply stability. The challenge lies in gathering and collating ground s...
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Open AccessThe factors affecting the performance of the tunnel wall drilling task and their priority
Clarifying the relationship between the man–machine environment and its impact on the tunnel wall drilling task performance (TWDTP) is crucial for enhancing the task performance. Based on a questionnaire surve...
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Open AccessMetabolomics facilitates differential diagnosis in common inherited retinal degenerations by exploring their profiles of serum metabolites
The diagnosis of inherited retinal degeneration (IRD) is challenging owing to its phenotypic and genotypic complexity. Clinical information is important before a genetic diagnosis is made. Metabolomics studies...
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Open AccessCollapse of carbon nanotubes due to local high-pressure from van der Waals encapsulation
Van der Waals (vdW) assembly of low-dimensional materials has proven the capability of creating structures with on-demand properties. It is predicted that the vdW encapsulation can induce a local high-pressure...
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Open AccessLipopolysaccharide binding protein resists hepatic oxidative stress by regulating lipid droplet homeostasis
Oxidative stress-induced lipid accumulation is mediated by lipid droplets (LDs) homeostasis, which sequester vulnerable unsaturated triglycerides into LDs to prevent further peroxidation. Here we identify the ...
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Open AccessIntegration of pathologic characteristics, genetic risk and lifestyle exposure for colorectal cancer survival assessment
The development of an effective survival prediction tool is key for reducing colorectal cancer mortality. Here, we apply a three-stage study to devise a polygenic prognostic score (PPS) for stratifying colorec...
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Open AccessPublisher Correction: Twisted moiré conductive thermal metasurface