-
Article
Open AccessCorrelation between CFTR variants and outcomes of ART in patients with CAVD in Central China
Biallelic variants in Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) are the main pathogenic factor of congenital absence of the vas deferens (CAVD), including congenital bilateral absence of the vas ...
-
Article
Effects of oocyte vitrification on gene expression in the liver and kidney tissues of adult offspring
Oocyte vitrification is an important assisted reproductive technology (ART) that preserves the fertility of unmarried patients with malignant tumors, and promotes the development of the oocyte donation program...
-
Article
Open AccessPrevalence and associated factors of infertility among 20–49 year old women in Henan Province, China
Infertility is a reproductive health problem which affects not only individuals, families and social populations. Recently, the infertility rate in China has a trend of increase year by year, and few studies h...
-
Article
The role of miRNAs in polycystic ovary syndrome with insulin resistance
This review aims to summarize the key findings of several miRNAs and their roles in polycystic ovary syndrome with insulin resistance, characterize the disease pathogenesis, and establish a new theoretical bas...
-
Article
Amorphous manganese oxide as highly active catalyst for soot oxidation
A series of highly active amorphous manganese oxide catalysts for soot combustion were synthesized using colloidal solution combustion synthesis (CSCS) method. The surface morphological and structural properti...
-
Article
Exosomes derived from human umbilical cord mesenchymal stem cells repair injured endometrial epithelial cells
To investigate whether exosomes derived from human umbilical cord mesenchymal stem cells (hucMSC-derived exosomes) can repair injured endometrial epithelial cells (EECs).
-
Article
Open AccessSilencing of microRNA-146a alleviates the neural damage in temporal lobe epilepsy by down-regulating Notch-1
This study aimed to evaluate the specific regulatory roles of microRNA-146a (miRNA-146a) in temporal lobe epilepsy (TLE) and explore the related regulatory mechanisms. A rat model of TLE was established by int...
-
Article
Rap2B promotes cell adhesion, proliferation, migration and invasion of human glioma
Rap2B, a member of the GTP-binding proteins, is generally up-regulated in numerous types of tumors. Nevertheless, the influence and regulatory mechanisms of Rap2B in gliomas are still not corroborated. Therefo...
-
Article
Effect of surface and bulk palladium do** on the catalytic activity of La2Sn2O7 pyrochlore oxides for diesel soot oxidation
The soot combustion on Pd-doped La2Sn2O7 pyrochlore oxides was studied. Palladium promoter was doped into the pyrochlore system via two ways: bulk substitution (La2Sn1.9Pd0.1O7) and surface impregnation (Pd/La2Sn
-
Article
Open AccessSingle Cas9 nickase induced generation of NRAMP1 knockin cattle with reduced off-target effects
The CRISPR-Cas9 system is a widely utilized platform for transgenic animal production in various species, although its off-target effects should be addressed. Several applications of this tool have been propos...
-
Chapter and Conference Paper
Robust Zero Watermarking for 3D Triangular Mesh Models Based on Spherical Integral Invariants
At present, zero-watermarking algorithms can well resist geometric attacks and signal attacks. However, most of them are not robust to resampling attack. To solve the problem, this paper presents a robust zero...
-
Article
The growth and reproduction performance of TALEN-mediated β-lactoglobulin-knockout bucks
With the technological development of several engineered endonucleases (EENs), such as zinc-finger nucleases, transcription activator-like effector nucleases (TALENs) and CRISPR/Cas9, gene targeting by homolog...
-
Article
Open AccessGeneration of TALE nickase-mediated gene-targeted cows expressing human serum albumin in mammary glands
Targeting exogenous genes at milk protein loci via gene-targeting technology is an ideal strategy for producing large quantities of pharmaceutical proteins. Transcription- activator-like effector (TALE) nucleases...
-
Article
Open AccessGene targeting by TALEN-induced homologous recombination in goats directs production of β-lactoglobulin-free, high-human lactoferrin milk
β-Lactoglobulin (BLG) is a major goat’s milk allergen that is absent in human milk. Engineered endonucleases, including transcription activator-like effector nucleases (TALENs) and zinc-finger nucleases, enabl...
