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Article
Open AccessHigh BRCA1 gene expression increases the risk of early distant metastasis in ER+ breast cancers
Although the function of the BRCA1 gene has been extensively studied, the relationship between BRCA1 gene expression and tumor aggressiveness remains controversial in sporadic breast cancers. Because the BRCA1 pr...
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Article
Open AccessUsing an Event-History with Risk-Free Model to Study the Genetics of Alcoholism
Case–control genetic association studies typically ignore possible later disease onset in currently healthy subjects and assume that subjects with diseases equally contribute to the likelihood for inference, r...
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Article
Open AccessSelection of DDX5 as a novel internal control for Q-RT-PCR from microarray data using a block bootstrap re-sampling scheme
The development of microarrays permits us to monitor transcriptomes on a genome-wide scale. To validate microarray measurements, quantitative-real time-reverse transcription PCR (Q-RT-PCR) is one of the most r...
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Article
Validation of A Heteroscedastic Hazards Regression Model
A Cox-type regression model accommodating heteroscedasticity, with a power factor of the baseline cumulative hazard, is investigated for analyzing data with crossing hazards behavior. Since the approach of par...
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Article
The prevalence of heavy proteinuria and progression risk factors in children undergoing urinary screening
To evaluate the prevalence and incidence density of heavy proteinuria and chronic renal insufficiency (CRI) and the factors related to disease progression, 10,288,620 urinary screenings of elementary and junio...
