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Article
Open AccessIdentification and validation of a lactate metabolism-related six-gene prognostic signature in intrahepatic cholangiocarcinoma
Intrahepatic cholangiocarcinoma (iCCA) is a highly malignant and fatal liver tumor with increasing incidence worldwide. Lactate metabolism has been recently reported as a crucial contributor to tumor progressi...
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Article
Open AccessProgress, application and challenges of liver organoids
The liver, the largest solid organ in the body, is susceptible to metabolic diseases and malignant tumors. Studying its physiological and pathological processes helps to optimize the clinical treatment. Organo...
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Chapter and Conference Paper
MARL for Traffic Signal Control in Scenarios with Different Intersection Importance
Recent efforts that applied Multi-Agent Reinforcement Learning (MARL) to the adaptive traffic signal control (ATSC) problem have shown remarkable progress. However, those methods assume that all agents in the ...
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Article
Bisphenol A induces ovarian cancer cell proliferation and metastasis through estrogen receptor-α pathways
Bisphenol A (BPA) is a widely used raw material that can be detected both in the environment and in the human body. Due to its estrogen-like effects, wide concerns have been raised about the potential role of ...
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Article
Open AccessDyslipidemia and non-small cell lung cancer risk in Chinese population: a case-control study
Numerous studies reported that dyslipidemia was associated with cancer risk. However, few studies investigated the associations between dyslipidemia and non-small cell lung cancer (NSCLC).
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Chapter and Conference Paper
Robust Segmentation of Overlap** Cells in Cervical Cytology Using Light Convolution Neural Network
Automated segmentation of cells in cervical cytology images poses a great challenge due to the presence of fuzzy and overlap** cells, noisy background, and poor cytoplasmic contrast. We present an improved m...
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Article
Open AccessRapid alterations of cell cycle control proteins in human T lymphocytes in microgravity
In our study we aimed to identify rapidly reacting gravity-responsive mechanisms in mammalian cells in order to understand if and how altered gravity is translated into a cellular response. In a combination of...
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Article
17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration
Heat-shock protein 90 (Hsp90) functions as part of a multichaperone complex that folds, activates and assembles its client proteins. Androgen receptor (AR), a pathogenic gene product in spinal and bulbar muscu...
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Article
Leuprorelin rescues polyglutamine-dependent phenotypes in a transgenic mouse model of spinal and bulbar muscular atrophy
Spinal and bulbar muscular atrophy (SBMA) is an adult-onset motor neuron disease that affects males. It is caused by the expansion of a polyglutamine (polyQ) tract in androgen receptors. Female carriers are us...
