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  1. No Access

    Article

    Two- and three-dimensional quantitative structure–permeability relationship of flavonoids in Caco-2 cells using stepwise multiple linear regression (SMLR), partial least squares regression (PLSR), and pharmacophore (GALAHAD)-based comparative molecular similarity index analysis (COMSIA)

    Limited oral bioavailability has hindered the widespread use of flavonoids as bioactive substances. Several studies have been performed to evaluate the transport characteristics of flavonoids in the intestine...

    Gerard Bryan Gonzales, John Van Camp, Moises Zotti… in Medicinal Chemistry Research (2015)

  2. No Access

    Article

    Cu isotope fractionation response to oxidative stress in a hepatic cell line studied using multi-collector ICP-mass spectrometry

    Reactive oxygen species (ROS) are generated in biological processes involving electron transfer reactions and can act in a beneficial or deleterious way. When intracellular ROS levels exceed the cell’s anti-ox...

    María R. Flórez, Marta Costas-Rodríguez… in Analytical and Bioanalytical Chemistry (2018)

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    Living Reference Work Entry In depth

    Microbiome Metabolic Potency Towards Plant Bioactives and Consequences for Health Effects

    Plant-based bioactive molecules containing a (modified) hydrocarbon backbone may have diverse health-promoting effects, but because of large interindividual variability the cause-consequence relationship is di...

    Charlotte Grootaert, Tom Van de Wiele in Health Consequences of Microbial Interacti…

  4. No Access

    Reference Work Entry In depth

    Microbiome Metabolic Potency Towards Plant Bioactives and Consequences for Health Effects

    Plant-based bioactive molecules containing a (modified) hydrocarbon backbone may have diverse health-promoting effects, but because of large interindividual variability the cause-consequence relationship is di...

    Charlotte Grootaert, Tom Van de Wiele in Health Consequences of Microbial Interacti… (2020)