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Article
Open AccessCryptolepine inhibits hepatocellular carcinoma growth through inhibiting interleukin-6/STAT3 signalling
Diverse signalling pathways are involved in carcinogenesis and one of such pathways implicated in many cancers is the interleukin 6/signal transducer and activator of transcription 3 (IL-6/STAT3) signalling pa...
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Article
Open AccessPharmacotherapy of infertility in Ghana: retrospective study at the cape coast teaching hospital
Infertility is a major challenge for couples globally. Due to low income levels and the high cost of other assisted reproductive techniques, pharmacotherapy remain the major first line treatment option for inf...
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Article
Open AccessIn vitro anti-malarial interaction and gametocytocidal activity of cryptolepine
Discovery of novel gametocytocidal molecules is a major pharmacological strategy in the elimination and eradication of malaria. The high patronage of the aqueous root extract of the popular West African anti-m...
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Article
Open AccessIdentification of cryptolepine metabolites in rat and human hepatocytes and metabolism and pharmacokinetics of cryptolepine in Sprague Dawley rats
This study aims at characterizing the in vitro metabolism of cryptolepine using human and rat hepatocytes, identifying metabolites in rat plasma and urine after a single cryptolepine dose, and evaluating the s...
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Article
Open AccessAntibiotic use during pregnancy: a retrospective study of prescription patterns and birth outcomes at an antenatal clinic in rural Ghana
Babies are increasingly being exposed to antibiotics intrapartum in the bid to reduce neonatal and maternal deaths. Intrapartum antibiotic exposure, including even those considered safe in pregnancy, have been...
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Article
Open AccessErratum to: Synergistic anti-malarial action of cryptolepine and artemisinins
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Article
Open AccessSynergistic anti-malarial action of cryptolepine and artemisinins
Cryptolepine (CPE) is the major indoloquinoline isolated from the popular West African anti-malarial plant, Cryptolepis sanguinolenta. CPE possesses various pharmacological activities with potent anti-malarial ac...
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Article
Open AccessResponses of genes involved in cell cycle control to diverse DNA damaging chemicals in human lung adenocarcinoma A549 cells
Many anticancer agents and carcinogens are DNA damaging chemicals and exposure to such chemicals results in the deregulation of cell cycle progression. The molecular mechanisms of DNA damage-induced cell cycle...
