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Article
Open AccessExpression of Fascin-1 and its diagnostic value in liver cancer
Although some studies have reported on the expression and clinical significance of Fascin-1 (FSCN1) in liver cancer, the clinical application and differential diagnosis value of FSCN1 in liver cancer are still...
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Article
Relevance and mechanism of STAT3/miR-221-3p/Fascin-1 axis in EGFR TKI resistance of triple-negative breast cancer
The epidermal growth factor receptor 1 (EGFR) plays a crucial role in the progression of various malignant tumors and is considered a potential target for treating triple-negative breast cancer (TNBC). However...
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Article
Open AccessThe impact of Angiopoietin-2 genetic polymorphisms on susceptibility for malignant breast neoplasms
Breast cancer causes morbidity and mortality among women worldwide, despite much research illuminating the genetic basis of this disease. Anti-angiogenesis therapies have been widely studied, although the asso...
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Article
Air-core characteristics in a swirling tunnel flow
A cost-effective technique to dissipate the energy in hydropower systems is the formation of a swirling flow within a tunnel. In such flows, an air core with a significant cross section usually occurs. To reve...
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Article
Open AccessUpregulated WTAP expression appears to both promote breast cancer growth and inhibit lymph node metastasis
It is unclear as to whether Wilms’ tumor 1-associated protein (WTAP) promotes or suppresses breast cancer. This immunohistochemistry analysis explored levels of WTAP expression in 347 cases of breast cancer an...
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Article
Benzosuberyl Substituents as a “Sandwich-like” Function in Olefin Polymerization Catalysis
For the rational design of metal catalyst in olefin polymerization catalysis, various strategies were applied to suppress the chain transfer by bulking up the axial positions of the metal center, among which t...
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Article
Open AccessIsolation and characterization of exosomes for cancer research
Exosomes are a subset of extracellular vesicles that carry specific combinations of proteins, nucleic acids, metabolites, and lipids. Mounting evidence suggests that exosomes participate in intercellular commu...
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Article
Open AccessSubcellular localization of HMGB1 in colorectal cancer impacts on tumor grade and survival prognosis
The high-mobility group box-1 (HMGB1) protein is implicated in the development of various cancers and their proliferation. According to its function, HMGB1 shuttles between the cell nucleus and cytoplasm, assi...
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Article
Improvement and Application of Acute Blood Stasis Rat Model Aligned with the 3Rs (Reduction, Refinement and Replacement) of Humane Animal Experimentation
To establish a novel cardiocentesis method for withdrawing venous blood from the right atrium, and to improve an acute blood stasis rat model using an ice bath and epinephrine hydrochloride (Epi) while conside...
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Article
Open AccessIncreased neutrophil extracellular traps promote metastasis potential of hepatocellular carcinoma via provoking tumorous inflammatory response
The propensity of the activated neutrophils to form extracellular traps (NETs) is demonstrated in multiple inflammatory conditions. In this study, we investigated the roles of NETs in metastasis of hepatocellu...
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Article
Open AccessOsteopontin promotes metastasis of intrahepatic cholangiocarcinoma through recruiting MAPK1 and mediating Ser675 phosphorylation of β-Catenin
The incidence and mortality of intrahepatic cholangiocarcinoma (ICC) are increasing worldwide in recent decades. Osteopontin (OPN) plays an important role in cancer metastasis, but its functional mechanism in ...
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Article
Open AccessFSCN1 gene polymorphisms: biomarkers for the development and progression of breast cancer
Breast cancer is a major cause of cancer mortality worldwide. Fascin-1 (FSCN1) is an actin-binding protein found in mammalian cells, including endothelial, neuronal and mesenchymal cells. FSCN1 overexpression ...
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Article
Open AccessEGFR conjunct FSCN1 as a Novel Therapeutic Strategy in Triple-Negative Breast Cancer
Emerging evidence indicates that Fascin-1 (FSCN1) may possess a causal role in the development of several types of cancers and serves as a novel biomarker of aggressiveness in certain carcinomas. However, the ...
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Article
Aureoboletus formosus, a new bolete species from Hunan Province of China
A new species, Aureoboletus formosus, from Hunan Province of China, is described based on morphological and molecular data. Morphologically, the new species can be distinguished from other species by the combinat...
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Article
Marasmius albopurpureus, a new species of section Globulares from Baili Island, China
Marasmius albopurpureus, a new species belonging to section Globulares, was found on a subtropical island, Baili Island, in southern China. It is characterized by its white to purple rugulose to ...
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Article
APF lncRNA regulates autophagy and myocardial infarction by targeting miR-188-3p
The abnormal autophagy is associated with a variety of cardiovascular diseases. Long noncoding RNAs (lncRNAs) are emerging as new factors in gene regulation, but how lncRNAs operate in the regulation of autoph...
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Article
Comparative studies of saponins in 1–3-year-old main roots, fibrous roots, and rhizomes of Panax notoginseng, and identification of different parts and growth-year samples
Notoginsenosides R1, R4, Fa, and K (N-R1, N-R4, N-Fa, and N-K), as well as ginsenosides Rg1, Rb1, Rd, Re, Rf, Rg2 and Rh1 (G-Rg1, G-Rb1, G-Rd, G-Re, G-Rf, G-Rg2 and G-Rh1) in 47 Notoginseng samples including 1-, ...
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Article
Open AccessLoss of miR-133a expression associated with poor survival of breast cancer and restoration of miR-133a expression inhibited breast cancer cell growth and invasion
miRNAs, endogenous oligonucleotide RNAs, play an important role in mammary gland carcinogenesis and tumor progression. Detection of their expression and investigation of their functions could lead to discovery...
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Article
Open AccessMiR-339-5p inhibits breast cancer cell migration and invasion in vitro and may be a potential biomarker for breast cancer prognosis
MicroRNAs (miRNAs) play an important role in the regulation of cell growth, differentiation, apoptosis, and carcinogenesis. Detection of their expression may lead to identifying novel markers for breast cancer.
