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Article
Open AccessImpact of Baseline Neuropathy Severity on Vutrisiran Treatment Response in the Phase 3 HELIOS-A Study
Hereditary transthyretin (ATTRv, v for variant) amyloidosis is a rare, progressive, fatal disease with multisystem manifestations, caused by pathogenic variants in the transthyretin (TTR) gene. Vutrisiran, an RNA...
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Article
Improvement of Corrosion and Wear Resistance of Mg-Li Alloy by Binary- and Ternary-Layered Double Hydroxide/Steam Coating Composite Coatings
In order to improve the corrosion resistance and frictional wear resistance of LA43M Mg-Li alloy, Mg-Al-layered double hydroxide (LDH)/steam coating (SC) and Mg-Al-Co LDH/SC composite coatings were prepared on...
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Article
Open AccessDetection and diagnosis of automated breast ultrasound in patients with BI-RADS category 4 microcalcifications: a retrospective study
Automated Breast Ultrasound (AB US) has shown good application value and prospects in breast disease screening and diagnosis. The aim of the study was to explore the ability of AB US to detect and diagnose mam...
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Article
Thin-Film Buckling Theory and Clinical Application of the Mechanism of Double Eyelid Formation
The mechanism underlying the formation of upper eyelid creases has been the subject of extensive study and ongoing debate. This research aims to elucidate the principles of upper eyelid creases formation, leve...
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Article
Open AccessInsights into chloroplast genome evolution in Rutaceae through population genomics
Chloroplast genomes, pivotal for understanding plant evolution, remain unexplored in Rutaceae, a family with key perennial crops like citrus. Leveraging next-generation sequencing data from 509 Rutaceae access...
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Article
Develop a radiomics-based machine learning model to predict the stone-free rate post-percutaneous nephrolithotomy
Radiomics and machine learning have been extensively utilized in the realm of urinary stones, particularly in forecasting stone treatment outcomes. The objective of this study was to integrate clinical variabl...
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Article
Open AccessAltered gut microbiota in Taiwanese A97S predominant transthyretin amyloidosis with polyneuropathy
Increasing evidence suggests that gut microbiota alterations are related to development and phenotypes of many neuropsychiatric diseases. Here, we evaluated the fecal microbiota and its clinical correlates in ...
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Article
Open AccessNeutrophil CD64 index as a new early predictive biomarker for infected pancreatic necrosis in acute pancreatitis
Infectious pancreatic necrosis (IPN) is a serious complication of acute pancreatitis, and early recognition and timely intervention are the keys to improving clinical outcomes. The purpose of this study was to...
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Article
Open AccessDiagnostic significance of HRCT imaging features in adult mycoplasma pneumonia: a retrospective study
Mycoplasma pneumoniae pneumonia (MPP) often overlaps with the clinical manifestations and chest imaging manifestations of other types of community-acquired pneumonia (CAP). We retrospectively analyzed the clin...
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Article
Open AccessTafamidis decreased cardiac amyloidosis deposition in patients with Ala97Ser hereditary transthyretin cardiomyopathy: a 12-month follow-up cohort study
Transthyretin cardiac cardiomyopathy (ATTR-CM) is a rare but life-threatening disease. Tafamidis is an effective treatment for patients with ATTR-CM, however its long-term effects on cardiac remodeling and car...
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Article
Open AccessUp-regulation of CREB-1 regulates tendon adhesion in the injury tendon healing through the CREB-1/TGF-β3 signaling pathway
To explore the mechanism of the healing of tendon tissue and anti-adhesion, and to discuss the role of the transforming growth factor-β3 (TGF-β3)/cAMP response element binding protein-1 (CREB-1) signaling path...
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Article
Open AccessCharacteristics of Patients with Hereditary Transthyretin Amyloidosis-Polyneuropathy (ATTRv-PN) in NEURO-TTRansform, an Open-label Phase 3 Study of Eplontersen
Hereditary transthyretin (ATTRv) amyloidosis is a rare, severe, progressive, debilitating, and ultimately fatal disease caused by systemic deposition of transthyretin (TTR) amyloid fibrils. ATTRv amyloidosis o...
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Article
Open AccessEffectiveness of different antithrombotic agents in combination with tranexamic acid for venous thromboembolism prophylaxis and blood management after total knee replacement: a prospective randomized study
Tranexamic acid (TXA) has been widely applied in total knee arthroplasty (TKA) to significantly reduce perioperative blood loss and improve knee function recovery in patients after surgery. The choice of antit...
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Article
Chlorine-rich lithium argyrodites enables superior performances for solid-state Li–Se batteries at wide temperature range
All-solid-state Li–Se battery shows great potential as a candidate for next-generation energy storage devices due to its high energy density and safety. However, the low ionic conductivity of the solid electro...
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Article
Determining the suitability of definitive radiation therapy in patients with metastatic nasopharyngeal carcinoma based on PET/CT: a large cohort study
To determine patients with de novo metastatic nasopharyngeal carcinoma (mNPC) who would benefit from receiving definitive radiation therapy (DRT) along with their pre-existing palliative chemotherapy (PCT) by ...
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Article
An iterative approach for image fusion with dynamic gradient sparsity and anisotropic spectral–spatial total variation
Image with higher spectral and spatial resolution is extensively used in the field of image processing, such as satellite imaging, medical imaging, and geological exploration. However, it is challenging to obt...
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Article
Sphingopyxis yananensis sp. nov., a novel 2-nitropropane degrading bacterium isolated from a microbial fermentation bed substrate
A rod-shaped, Gram-negative staining strain, FBM22T, was isolated from a microbial fermentation bed substrate from a pig farm. Its colonies appeared yellow and were 0.5–1.2 mm in diameter. Cells were 0.3–0.5 μm w...
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The Role of the Surface on Bacteria-Implant Interactions
TKA prostheses postoperative infection (PJI) is the most terrible complication of this surgery with disastrous consequences. As the population ages and the demand for TKA continues to rise, the incidence of PJ...
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Article
Ultra-high-energy lithium-ion batteries enabled by aligned structured thick electrode design
电池制造有希望制备出具有可精细调控微观结构, 几何形状和厚度的高性能电极。然而, 厚电极面临着电子和锂离子传输缓慢的挑战。在这里, 我们制备出–种具有导向结构的厚电极, 作为实现高能锂离子电池的替代方法。开发了借助胶粘剂和单壁碳纳米管 (SWCNT) 的冷冻干燥工艺, 用于制备基于LiNi0.8Co0.1Mn0.1O2 (NCM811) 作为代表性**极电极材料的导向结构厚电极。1 mm厚的NCM811**极具有101 mg...
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Article
Optimal path planning method of electric vehicles considering power supply
Because of the limitations of electric vehicle (EV) battery technology and relevant supporting facilities, there is a great risk of breakdown of EVs during driving. The resulting driver “range anxiety” greatly...
