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Article
Open AccessA mechanical-assisted post-bioprinting strategy for challenging bone defects repair
Bioprinting that can synchronously deposit cells and biomaterials has lent fresh impetus to the field of tissue regeneration. However, the unavoidable occurrence of cell damage during fabrication process and i...
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Article
Open AccessGradient matters via filament diameter-adjustable 3D printing
Gradient matters with hierarchical structures endow the natural world with excellent integrity and diversity. Currently, direct ink writing 3D printing is attracting tremendous interest, and has been used to e...
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Article
Advanced strategies in the application of gelatin-based bioink for extrusion bioprinting
The significance of bioink suitability for the extrusion bioprinting of tissue-like constructs cannot be overemphasized. Gelatin, derived from the hydrolysis of collagen, not only can mimic the extracellular m...
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Article
Open AccessSmall-molecule amines: a big role in the regulation of bone homeostasis
Numerous small-molecule amines (SMAs) play critical roles in maintaining bone homeostasis and promoting bone regeneration regardless of whether they are applied as drugs or biomaterials. On the one hand, SMAs ...
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Article
Open AccessOsteoprotegerin deficiency aggravates methionine–choline-deficient diet-induced nonalcoholic steatohepatitis in mice
Clinical studies have shown that osteoprotegerin (OPG) is reduced in patients with nonalcoholic steatohepatitis (NASH), but the underlying mechanisms are unclear. The current study focuses on the role of OPG i...
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Article
Progranulin regulates the development and function of NKT2 cells through EZH2 and PLZF
T helper 2 (Th2) cytokine production by invariant natural killer T (iNKT) cells is involved in the development of asthma, but the regulation of Th2 cytokines in iNKT cells remains unknown. Although it is known...
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Article
Open AccessAn optogenetic approach for regulating human parathyroid hormone secretion
Parathyroid hormone (PTH) plays crucial role in maintaining calcium and phosphorus homeostasis. In the progression of secondary hyperparathyroidism (SHPT), expression of calcium-sensing receptors (CaSR) in the...
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Article
Open AccessAKT2 deficiency impairs formation of the BCR signalosome
AKT2 is one of the key molecules that involves in the insulin-induced signaling and the development of cancer. In B cells, the function of AKT2 is unclear.
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Article
Open AccessThe interfacial pH of acidic degradable polymeric biomaterials and its effects on osteoblast behavior
A weak alkaline environment is established to facilitate the growth of osteoblasts. Unfortunately, this is inconsistent with the application of biodegradable polymer in bone regeneration, as the degradation pr...
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Article
Effect of cellulose crystallinity on bacterial cellulose assembly
Bacterial cellulose (BC) is a promising biomaterial as well as a model system useful for investigating cellulose biosynthesis. BC produced under static cultivation condition is a hydrous pellicle consisting of...
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Article
Surface modification of paclitaxel-loaded tri-block copolymer PLGA-b-PEG-b-PLGA nanoparticles with protamine for liver cancer therapy
In order to enhance the therapeutic effect of chemotherapy on liver cancer, a biodegradable formulation of protamine-modified paclitaxel-loaded poly(lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(lactide-co
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Article
Melt synthesis and characterization of poly(L-lactic acid) chain linked by multifunctional epoxy compound
High molecular weight(Mw) poly(L-lactic acid)s(PLLAs) were synthesized using multifunctional epoxy compound(Joncryl-ADR4370) as chain extender. The products were characterized by gel permeation chromatography(...
