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  1. No Access

    Article

    Radiosynthesis of [11C]EI1 for imaging EZH2 using positron emission tomography

    Enhancer of zeste homolog 2 (EZH2) is responsible for the methylation of lysine 27 of histone H3 (H3K27) leading to transcriptional repression. Consequently, EZH2 is related with several diseases including can...

    Hao Wang, Yu Lan, ** Bai, Zude Chen, Shenglin Luo… in Medicinal Chemistry Research (2020)

  2. No Access

    Article

    Synthesis of a carbon-11 radiolabeled BACE1 inhibitor

    Beta-secretase (BACE1), a transmembrane aspartyl protease, can cleave membrane-bound β-amyloid precursor proteins (APPs) to initiate the accumulation of amyloid-β (Aβ). The inhibition of BACE-1 to limit the ac...

    Yiwei Zhu, Stephanie A. Fiedler, Matthew L. Hibert… in Medicinal Chemistry Research (2020)