8 Result(s)

Article

AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine

The shift of carbon utilization from primarily glucose to other nutrients is a fundamental metabolic adaptation to cope with decreased blood glucose levels and the consequent decline in glucose oxidation. AMP-...

Mengqi Li, Yu Wang, **aoyan Wei, Wei-Feng Cai, Jianfeng Wu, Mingxia Zhu… in Cell Research (2024)

Article

Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate

Glycolytic intermediary metabolites such as fructose-1,6-bisphosphate can serve as signals, controlling metabolic states beyond energy metabolism. However, whether glycolytic metabolites also play a role in co...

Yu-Qing Wu, Chen-Song Zhang, **ye **ong, Dong-Qi Cai, Chen-Zhe Wang… in Cell Research (2023)

Article

Clinical outcomes of de novo metastatic HER2-low breast cancer: a National Cancer Database Analysis

The development of novel anti-HER2 drugs opens new treatment options for women with breast cancers, including lower expression of HER2. The epidemiology and clinical outcome of metastatic HER2-low breast cance...

Changchuan Jiang, Stuthi Perimbeti, Lei Deng, Charles L. Shapiro… in npj Breast Cancer (2022)

Article

MiR-92a/KLF4/p110δ regulates titanium particles-induced macrophages inflammation and osteolysis

As total joint replacement is widely applied for severe arthropathy, peri-prosthetic aseptic loosening as one of the main causes of implant failure has drawn wide attention. Wear particles such as titanium par...

Zhenkang Wen, Sipeng Lin, Changchuan Li, Zhuji Ouyang, Zhong Chen… in Cell Death Discovery (2022)

Article

RIP1-dependent linear and nonlinear recruitments of caspase-8 and RIP3 respectively to necrosome specify distinct cell death outcomes

There remains a significant gap in our quantitative understanding of crosstalk between apoptosis and necroptosis pathways. By employing the SWATH-MS technique, we quantified absolute amounts of up to thousands...

**ang Li, Chuan-Qi Zhong, Rui Wu, **aozheng Xu, Zhang-Hua Yang… in Protein & Cell (2021)

Article

Aldolase is a sensor for both low and high glucose, linking to AMPK and mTORC1

Mengqi Li, Chen-Song Zhang, **-Wei Feng, **aoyan Wei, Cixiong Zhang… in Cell Research (2021)

Article

PI3K/AKT-mediated upregulation of WDR5 promotes colorectal cancer metastasis by directly targeting ZNF407

Colorectal cancer (CRC) is the third most common cause of cancer deaths, and has a high rate of liver and lung metastasis. Unfortunately, distant metastasis is the main barrier for advanced CRC therapy and lea...

**n Tan, Shuai Chen, Jiangxue Wu, Jiaxin Lin, Changchuan Pan… in Cell Death & Disease (2017)