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Article
Open AccessAltered small-world property of a dynamic metabolic network in murine left hippocampus after exposure to acute stress
The acute stress response is a natural and fundamental reaction that balances the physiological conditions of the brain. To maintain homeostasis in the brain, the response is based on changes over time in horm...
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Article
Open AccessDifferent ways to transport ammonia in human and Mycobacterium tuberculosis NAD+ synthetases
NAD+ synthetase is an essential enzyme of de novo and recycling pathways of NAD+ biosynthesis in Mycobacterium tuberculosis but not in humans. This bifunctional enzyme couples the NAD+ synthetase and glutaminase ...
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Article
Discovery of substituted pyrazol-4-yl pyridazinone derivatives as novel c-Met kinase inhibitors
A series of pyridazin-3-one substituted with morpholino-pyrimidine derivatives was synthesized and evaluated as tyrosine kinase inhibitors against c-Met enzyme, and anti-proliferative activities of Hs746T huma...
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Article
Novel 2,4-dianilino-5-fluoropyrimidine derivatives possessing ALK inhibitory activities
A new series of 2,4-dianilino-5-fluoropyrimidine derivatives were designed and synthesized and their anaplastic lymphoma kinase (ALK) inhibitory activities were evaluated by biochemical and cell-based assays i...
