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Article
Bcl-2 expression suppresses mismatch repair activity through inhibition of E2F transcriptional activity
Bcl-2 stimulates mutagenesis after the exposure of cells to DNA-damaging agents. However, the biological mechanisms of Bcl-2-mediated mutagenesis have remained largely obscure. Here we demonstrate that the Bcl...
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Article
The Anti-obesity Effect of Natural Vanadium-Containing Jeju Ground Water
This study investigated the anti-obesity effects of Jeju ground water containing the vanadium components S1 (8.0 ± 0.9 μg/l) and S3 (26.0 ± 2.09 μg/l) on the differentiation of 3 T3-L1 preadipocytes and obesit...
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Article
Open Access53BP1 contributes to regulation of autophagic clearance of mitochondria
Autophagy, the primary recycling pathway within cells, plays a critical role in mitochondrial quality control under normal growth conditions and in the cellular response to stress. Here we provide evidence tha...
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Article
Open AccessHspBP1 is a dual function regulatory protein that controls both DNA repair and apoptosis in breast cancer cells
The Hsp70-binding protein 1 (HspBP1) belongs to a family of co-chaperones that regulate Hsp70 activity and whose biological significance is not well understood. In the present study, we show that when HspBP1 i...