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  1. Article

    Open Access

    HspBP1 is a dual function regulatory protein that controls both DNA repair and apoptosis in breast cancer cells

    The Hsp70-binding protein 1 (HspBP1) belongs to a family of co-chaperones that regulate Hsp70 activity and whose biological significance is not well understood. In the present study, we show that when HspBP1 i...

    Cha Kyung Youn, Jung-Hee Lee, Gurusamy Hariharasudhan… in Cell Death & Disease (2022)

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  2. Article

    Open Access

    53BP1 contributes to regulation of autophagic clearance of mitochondria

    Autophagy, the primary recycling pathway within cells, plays a critical role in mitochondrial quality control under normal growth conditions and in the cellular response to stress. Here we provide evidence tha...

    Cha Kyung Youn, Hong Beum Kim, Ting Ting Wu, Sanggon Park… in Scientific Reports (2017)

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  3. No Access

    Article

    The Anti-obesity Effect of Natural Vanadium-Containing Jeju Ground Water

    This study investigated the anti-obesity effects of Jeju ground water containing the vanadium components S1 (8.0 ± 0.9 μg/l) and S3 (26.0 ± 2.09 μg/l) on the differentiation of 3 T3-L1 preadipocytes and obesit...

    Seon-Joo Park, Cha-Kyung Youn, ** Won Hyun… in Biological Trace Element Research (2013)

  4. No Access

    Article

    Bcl-2 expression suppresses mismatch repair activity through inhibition of E2F transcriptional activity

    Bcl-2 stimulates mutagenesis after the exposure of cells to DNA-damaging agents. However, the biological mechanisms of Bcl-2-mediated mutagenesis have remained largely obscure. Here we demonstrate that the Bcl...

    Cha-Kyung Youn, Hyun-Ju Cho, Soo-Hyun Kim, Hong-Beum Kim, Mi-Hwa Kim… in Nature Cell Biology (2005)