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Article
Open AccessInhibition of WNT/β-catenin signalling during sex-specific gonadal differentiation is essential for normal human fetal testis development
Sex-specific gonadal differentiation is directed by complex signalling promoting development in either male or female direction, while simultaneously inhibiting the opposite pathway. In mice, the WNT/β-catenin...
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Article
Open AccessIdentification of a window of androgen sensitivity for somatic cell function in human fetal testis cultured ex vivo
Reduced androgen action during early fetal development has been suggested as the origin of reproductive disorders comprised within the testicular dysgenesis syndrome (TDS). This hypothesis has been supported b...
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Article
Open AccessThe effects of selected inhibitors on human fetal adrenal steroidogenesis differs under basal and ACTH-stimulated conditions
Disordered fetal adrenal steroidogenesis can cause marked clinical effects including virilization of female fetuses. In postnatal life, adrenal disorders can be life-threatening due to the risk of adrenal cris...
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Article
Involvement of the DNA mismatch repair system in cisplatin sensitivity of testicular germ cell tumours
Testicular germ cell tumours (TGCT) are highly sensitive to cisplatin-based chemotherapy, but patients with tumours containing differentiated teratoma components are less responsive to this treatment. The cisp...
