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Article
Open AccessQuality control material for the detection of somatic mutations in fixed clinical specimens by next-generation sequencing
Targeted next generation sequencing (NGS) technology to assess the mutational status of multiple genes on formalin-fixed, paraffin embedded (FFPE) tumors is rapidly being adopted in clinical settings, where qu...
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Article
Open AccessMolecular signatures mostly associated with NK cells are predictive of relapse free survival in breast cancer patients
Recent observations suggest that immune-mediated tissue destruction is dependent upon coordinate activation of immune genes expressed by cells of the innate and adaptive immune systems.
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Article
Open AccessApplication of a correlation correction factor in a microarray cross-platform reproducibility study
Recent research examining cross-platform correlation of gene expression intensities has yielded mixed results. In this study, we demonstrate use of a correction factor for estimating cross-platform correlations.
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Article
BCRABL Transcript Detection by Quantitative Real-Time PCR
Background: Quantitative real-time PCR has become the predominant molecular technique to monitor BCRABL levels in response to treatment in Ph+ leukemia patients. However, without some form of sta...
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Article
Open AccessGraphical technique for identifying a monotonic variance stabilizing transformation for absolute gene intensity signals
The usefulness of log2 transformation for cDNA microarray data has led to its widespread application to Affymetrix data. For Affymetrix data, where absolute intensities are indicative of number of transcripts, th...
