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Article
Cannabinoid tetrad effects of oral Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in male and female rats: sex, dose-effects and time course evaluations
The legalization of medicinal use of Cannabis sativa in most US states and the removal of hemp from the Drug Enforcement Agency (DEA) controlled substances act has resulted in a proliferation of products containi...
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Article
Open AccessGut microbiome and metabolome in a non-human primate model of chronic excessive alcohol drinking
A relationship between the gut microbiome and alcohol use disorder has been suggested. Excessive alcohol use produces changes in the fecal microbiome and metabolome in both rodents and humans. Yet, these chang...
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Article
Reward sensitivity deficits in a rat model of compulsive eating behavior
Compulsive eating behavior is hypothesized to be driven in part by reward deficits likely due to neuroadaptations to the mesolimbic dopamine (DA) system. Therefore, the aim of this study was to assess deficits...
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Article
The Trace Amine-Associated Receptor 1 Agonist RO5256390 Blocks Compulsive, Binge-like Eating in Rats
Compulsive, binge eating of highly palatable food constitutes a core feature of some forms of obesity and eating disorders, as well as of the recently proposed disorder of food addiction. Trace amine-associate...
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Article
Pathological Overeating: Emerging Evidence for a Compulsivity Construct
Compulsive eating behavior is a transdiagnostic construct that is characteristic of medical and psychiatric conditions such as forms of obesity and eating disorders. Although feeding research is moving toward ...
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Article
High Trait Impulsivity Predicts Food Addiction-Like Behavior in the Rat
Impulsivity is a behavioral trait frequently seen not only in drug-addicted individuals but also in individuals who pathologically overeat. However, whether impulsivity predates the development of uncontrollab...
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Article
Sex differences in the effect of wheel running on subsequent nicotine-seeking in a rat adolescent-onset self-administration model
Wheel running attenuates nicotine-seeking in male adolescent rats; however, it is not known if this effect extends to females.
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Article
Effect of wheel-running during abstinence on subsequent nicotine-seeking in rats
Exercise appears to be a promising non-pharmacological treatment for nicotine addiction that may be useful for the vulnerable adolescent population.