12 Result(s)

Article

Using mass spectrometry to validate mouse models of tauopathy

Yan Yan, Casey N. Cook in Molecular Neurodegeneration (2023)

Article

Author Correction: Toxic expanded GGGGCC repeat transcription is mediated by the PAF1 complex in C9orf72-associated FTD

Lindsey D. Goodman, Mercedes Prudencio, Nicholas J. Kramer… in Nature Neuroscience (2023)

Article

Evidence of cerebellar TDP-43 loss of function in FTLD-TDP

Frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) is a neurodegenerative disease primarily affecting the frontal and/or temporal cortices. However, a growing body of evidence suggests that the...

Sarah Pickles, Tania F. Gendron, Yuka Koike… in Acta Neuropathologica Communications (2022)

Article

TDP-43 represses cryptic exon inclusion in the FTD–ALS gene UNC13A

A hallmark pathological feature of the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is the depletion of RNA-binding protein TDP-43 from the nucleus of neuron...

X. Rosa Ma, Mercedes Prudencio, Yuka Koike, Sarat C. Vatsavayai, Garam Kim… in Nature (2022)

Article

Clusterin ameliorates tau pathology in vivo by inhibiting fibril formation

The molecular chaperone Clusterin (CLU) impacts the amyloid pathway in Alzheimer’s disease (AD) but its role in tau pathology is unknown. We observed CLU co-localization with tau aggregates in AD and primary t...

Aleksandra M. Wojtas, Yari Carlomagno… in Acta Neuropathologica Communications (2020)

Article

Tau exhibits unique seeding properties in globular glial tauopathy

Tauopathies are neurodegenerative disorders characterized by aggregation of microtubule associated tau protein in neurons and glia. They are clinically and pathologically heterogeneous depending on the isoform...

Dah-eun Chloe Chung, Yari Carlomagno, Casey N. Cook… in Acta Neuropathologica Communications (2019)

Article

Replication of progressive supranuclear palsy genome-wide association study identifies SLCO1A2 and DUSP10 as new susceptibility loci

Progressive supranuclear palsy (PSP) is a parkinsonian neurodegenerative tauopathy affecting brain regions involved in motor function, including the basal ganglia, diencephalon and brainstem. While PSP is larg...

Monica Y. Sanchez-Contreras, Naomi Kouri, Casey N. Cook… in Molecular Neurodegeneration (2018)

Article

The lysosomal protein cathepsin L is a progranulin protease

Haploinsufficiency of GRN, the gene encoding progranulin (PGRN), causes frontotemporal lobar degeneration (FTLD), the second most common cause of early-onset dementia. Receptor-mediated lysosomal targeting has...

Chris W. Lee, Jeannette N. Stankowski, Jeannie Chew… in Molecular Neurodegeneration (2017)

Article

An autoradiographic evaluation of AV-1451 Tau PET in dementia

It is essential to determine the specificity of AV-1451 PET for tau in brain imaging by using pathological comparisons. We performed autoradiography in autopsy-confirmed Alzheimer disease and other neurodegene...

Val J. Lowe, Geoffry Curran, ** Fang… in Acta Neuropathologica Communications (2016)