16 Result(s)
within
Carel F. W. Peeters
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Article
Open AccessA guided network estimation approach using multi-omic information
In systems biology, an organism is viewed as a system of interconnected molecular entities. To understand the functioning of organisms it is essential to integrate information about the variations in the conce...
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Article
Open AccessCSF proteome profiling reveals biomarkers to discriminate dementia with Lewy bodies from Alzheimer´s disease
Diagnosis of dementia with Lewy bodies (DLB) is challenging and specific biofluid biomarkers are highly needed. We employed proximity extension-based assays to measure 665 proteins in the cerebrospinal fluid (...
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Article
CSF proteome profiling across the Alzheimer’s disease spectrum reflects the multifactorial nature of the disease and identifies specific biomarker panels
Development of disease-modifying therapies against Alzheimer’s disease (AD) requires biomarkers reflecting the diverse pathological pathways specific for AD. We measured 665 proteins in 797 cerebrospinal fluid...
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Article
Open AccesspsBLUP: incorporating marker proximity for improving genomic prediction accuracy
Genomic selection entails the estimation of phenotypic traits of interest for plants without phenotype based on the association between single-nucleotide polymorphisms (SNPs) and phenotypic traits for plants w...
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Article
Open AccessSymptom clusters among cancer survivors: what can machine learning techniques tell us?
Knowledge regarding symptom clusters may inform targeted interventions. The current study investigated symptom clusters among cancer survivors, using machine learning techniques on a large data set.
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Article
Open AccessMultiparametric functional MRI and 18F-FDG-PET for survival prediction in patients with head and neck squamous cell carcinoma treated with (chemo)radiation
To assess (I) correlations between diffusion-weighted (DWI), intravoxel incoherent motion (IVIM), dynamic contrast-enhanced (DCE) MRI, and 18F-FDG-PET/CT imaging parameters capturing tumor characteristics and (II...
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Article
Open AccessOutcome prediction of head and neck squamous cell carcinoma by MRI radiomic signatures
Head and neck squamous cell carcinoma (HNSCC) shows a remarkable heterogeneity between tumors, which may be captured by a variety of quantitative features extracted from diagnostic images, termed radiomics. Th...
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Article
Open AccessPredictive value of quantitative 18F-FDG-PET radiomics analysis in patients with head and neck squamous cell carcinoma
Radiomics is aimed at image-based tumor phenoty**, enabling application within clinical-decision-support-systems to improve diagnostic accuracy and allow for personalized treatment. The purpose was to identi...
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Article
Open AccessThe spectral condition number plot for regularization parameter evaluation
Many modern statistical applications ask for the estimation of a covariance (or precision) matrix in settings where the number of variables is larger than the number of observations. There exists a broad class...
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Article
Open AccessCross-cultural validation of the Functional Vision Questionnaire for Children and Young People (FVQ_CYP) with visual impairment in the Dutch population: challenges and opportunities
To assess cross-cultural validity between Dutch and English versions of the FVQ_CYP, a patient-reported outcome measure developed in the United Kingdom (UK) for children and adolescents with (severe) visual im...
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Article
Open AccessWho provides care in the last year of life? A description of care networks of community-dwelling older adults in the Netherlands
Home-based care networks differ in size and composition, but little is known about the characteristics of care networks for those nearing the end of their lives. This study aimed to identify different types of...
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Article
Zorgnetwerken
De meeste mensen willen tot het eind van hun leven thuis blijven. Om dat mogelijk te maken, is mantelzorg cruciaal. Maar welke mantelzorgers en andere zorgverleners zijn er eigenlijk betrokken bi...
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Chapter and Conference Paper
Application of a New Ridge Estimator of the Inverse Covariance Matrix to the Reconstruction of Gene-Gene Interaction Networks
A proper ridge estimator of the inverse covariance matrix is presented. We study the properties of this estimator in relation to other ridge-type estimators. In the context of Gaussian graphical modeling, we c...
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Article
Methodological Issues in the Design of Online Surveys for Measuring Unethical Work Behavior: Recommendations on the Basis of a Split-Ballot Experiment
In recent years, there has been an increasing interest in unethical work behavior. Several types of survey instruments to collect information about unethical work behavior are available. Nevertheless, to date ...
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Article
Rotational Uniqueness Conditions Under Oblique Factor Correlation Metric
In an addendum to his seminal 1969 article Jöreskog stated two sets of conditions for rotational identification of the oblique factor solution under utilization of fixed zero elements in the factor loadings ma...
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Chapter
Inequality Constrained Multilevel Models
In many areas of research, datasets have a multilevel or hierarchical structure. By hierarchy we mean that units at a certain level are grouped or clustered into, or nested within, higher-level units. The “lev...
