4,393 Result(s)
within
Cao **e
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessNLRC5 promotes tumorigenesis by regulating the PI3K/AKT signaling pathway in cervical cancer
Cervical cancer (CC) is the fourth most common cancer among women worldwide. NLR Family CARD Domain Containing 5 (NLRC5) plays an important role in tumorigenesis. However, its effect and mechanism in CC remain...
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Open AccessDCAF15 control of cohesin dynamics sustains acute myeloid leukemia
The CRL4-DCAF15 E3 ubiquitin ligase complex is targeted by the aryl-sulfonamide molecular glues, leading to neo-substrate recruitment, ubiquitination, and proteasomal degradation. However, the physiological fu...
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Open AccessLiquid-liquid reactions performed by cellular reactors
Liquid-liquid reactions play a significant role in organic synthesis. However, control of the phase interface between incompatible two-phase liquids remains challenging. Moreover, separating liquid acid, base ...
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Open AccessA rapid aureochrome opto-switch enables diatom acclimation to dynamic light
Diatoms often outnumber other eukaryotic algae in the oceans, especially in coastal environments characterized by frequent fluctuations in light intensity. The identities and operational mechanisms of regulato...
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Open AccessNeutrophil extracellular traps-inspired DNA hydrogel for wound hemostatic adjuvant
Severe traumatic bleeding may lead to extremely high mortality rates, and early intervention to stop bleeding plays as a critical role in saving lives. However, rapid hemostasis in deep non-compressible trauma...
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Open AccessMyricetin mitigates motor disturbance and decreases neuronal ferroptosis in a rat model of Parkinson’s disease
Ferroptosis is an iron-dependent cell death form characterized by reactive oxygen species (ROS) overgeneration and lipid peroxidation. Myricetin, a flavonoid that exists in numerous plants, exhibits potent ant...
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Author Correction: Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing
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Open AccessRole of atmospheric rivers in sha** long term Arctic moisture variability
Atmospheric rivers (ARs) reaching high-latitudes in summer contribute to the majority of climatological poleward water vapor transport into the Arctic. This transport has exhibited long term changes over the p...
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Open AccessPIKfyve, expressed by CD11c-positive cells, controls tumor immunity
Cancer treatment continues to shift from utilizing traditional therapies to targeted ones, such as protein kinase inhibitors and immunotherapy. Mobilizing dendritic cells (DC) and other myeloid cells with anti...
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Open AccessA global dataset of the fraction of absorbed photosynthetically active radiation for 1982–2022
The fraction of absorbed photosynthetically active radiation (FPAR) is an essential biophysical parameter that characterizes the structure and function of terrestrial ecosystems. Despite the extensive utilizat...
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Open AccessHeterodimensional Kondo superlattices with strong anisotropy
Localized magnetic moments in non-magnetic materials, by interacting with the itinerary electrons, can profoundly change the metallic properties, develo** various correlated phenomena such as the Kondo effec...
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Open AccessMulti-optimization for thermal deformation of gravitational wave telescope based on CFRP characteristics
Gravitational wave telescope place extremely high demands on structural thermal deformation, making material selection a critical issue. Carbon fiber reinforced polymer (CFRP) is an ideal choice for the suppor...
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Open AccessSpatiotemporal optical vortices with controllable radial and azimuthal quantum numbers
Optical spatiotemporal vortices with transverse photon orbital angular momentum (OAM) have recently become a focal point of research. In this work we theoretically and experimentally investigate optical spatio...
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Open AccessNuclear and mitochondrial genomes of the plum fruit moth Grapholita funebrana
The plum fruit moth Grapholita funebrana (Tortricidae, Lepidoptera) is an important pest of many wild and cultivated stone fruits and other plants in the family Rosaceae. Here, we assembled its nuclear and mitoch...
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Open AccessDiscovering type I cis-AT polyketides through computational mass spectrometry and genome mining with Seq2PKS
Type 1 polyketides are a major class of natural products used as antiviral, antibiotic, antifungal, antiparasitic, immunosuppressive, and antitumor drugs. Analysis of public microbial genomes leads to the disc...
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Open AccessStructural and mechanistic insights into a lysosomal membrane enzyme HGSNAT involved in Sanfilippo syndrome
Heparan sulfate (HS) is degraded in lysosome by a series of glycosidases. Before the glycosidases can act, the terminal glucosamine of HS must be acetylated by the integral lysosomal membrane enzyme heparan-α-...
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Open AccessSDS22 coordinates the assembly of holoenzymes from nascent protein phosphatase-1
SDS22 forms an inactive complex with nascent protein phosphatase PP1 and Inhibitor-3. SDS22:PP1:Inhibitor-3 is a substrate for the ATPase p97/VCP, which liberates PP1 for binding to canonical regulatory subuni...
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Open AccessComprehensive evaluation of drought tolerance of six Chinese chestnut varieties (clones) based on flavonoids and other physiological indexes
Flavonoids are crucial secondary metabolites that possess the ability to mitigate UV damage and withstand both biotic and abiotic stresses. Therefore, it is of immense significance to investigate the flavonoid...
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Open AccessPotential diagnostic biomarkers for immunogenic cell death in elderly female patients with ischemic stroke: identification and analysis
Ischemic stroke (IS) is of increasing concern given the aging population and prevalence of unhealthy lifestyles, with older females exhibiting higher susceptibility. This study aimed to identify practical diag...
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Open AccessCharacterization of a Lactobacillus gasseri strain as a probiotic for female vaginitis
Vaginitis, a prevalent gynecological condition in women, is mainly caused by an imbalance in the vaginal micro-ecology. The two most common types of vaginitis are vaginal bacteriosis and vulvovaginal candidias...
