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  1. Article

    Open Access

    Dihydromyricetin affects BDNF levels in the nervous system in rats with comorbid diabetic neuropathic pain and depression

    Diabetic neuropathic pain (DNP) and depression (DP) are the common complications in patients with diabetes. The purpose of our research was to observe whether brain-derived neurotrophic factor (BDNF) levels an...

    Huixiang Ge, Shu Guan, Yulin Shen, Mengyun Sun, Yuanzhen Hao in Scientific Reports (2019)

  2. Article

    Open Access

    Effects of palmatine on BDNF/TrkB-mediated trigeminal neuralgia

    Trigeminal neuralgia (TN), a sudden, needle-like pain in the distribution area of the trigeminal nerve, can seriously affect the physical and mental health of patients. In chronic pain conditions including TN,...

    Lijuan Liu, Lingkun He, Cancan Yin, Ruoyu Huang, Wenhao Shen in Scientific Reports (2020)

  3. Article

    Open Access

    Modulating tumour metabolism enhances gold nanoparticle radiosensitisation in HPV-negative head and neck cancer

    Radiotherapy is a major therapeutic modality for locally advanced head and neck cancer. However, the effectiveness of radiotherapy is hindered by resistance mechanisms, most notably hypoxia, leading to unfavou...

    Jie Feng, Varun Pathak, Niall M. Byrne, Tongchuan Wang, Cancan Yin in Cancer Nanotechnology (2023)