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  1. No Access

    Article

    Translation readthrough mitigation

    Translation termination sequences are occasionally bypassed by the ribosome and the resulting proteins can be detrimental to the cell; here it is shown that cells can prevent such proteins from accumulating th...

    Joshua A. Arribere, Elif S. Cenik, Nimit Jain, Gaelen T. Hess, Cameron H. Lee… in Nature (2016)

  2. No Access

    Article

    Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells

    Recruiting a hyperactive cytidine deaminase via the guide RNA to dCas9 allows for the introduction of diverse point mutations at the CRISPR target locus to create complex libraries of variants for protein engi...

    Gaelen T Hess, Laure Frésard, Kyuho Han, Cameron H Lee, Amy Li… in Nature Methods (2016)

  3. No Access

    Article

    Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators

    The retrotransposition of L1 is controlled by functionally diverse genes at the transcriptional or post-transcriptional levels, and its silencing can lead to the downregulation of host gene expression.

    Nian Liu, Cameron H. Lee, Tomek Swigut, Edward Grow, Bo Gu, Michael C. Bassik… in Nature (2018)

  4. Article

    Open Access

    The integral spliceosomal component CWC15 is required for development in Arabidopsis

    Efficient mRNA splicing is a prerequisite for protein biosynthesis and the eukaryotic splicing machinery is evolutionarily conserved among species of various phyla. At its catalytic core resides the activated ...

    Daniel Slane, Cameron H. Lee, Martina Kolb, Craig Dent, Ying**g Miao… in Scientific Reports (2020)

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