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Article
Open AccessThe integral spliceosomal component CWC15 is required for development in Arabidopsis
Efficient mRNA splicing is a prerequisite for protein biosynthesis and the eukaryotic splicing machinery is evolutionarily conserved among species of various phyla. At its catalytic core resides the activated ...
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Article
Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators
The retrotransposition of L1 is controlled by functionally diverse genes at the transcriptional or post-transcriptional levels, and its silencing can lead to the downregulation of host gene expression.
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Article
Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells
Recruiting a hyperactive cytidine deaminase via the guide RNA to dCas9 allows for the introduction of diverse point mutations at the CRISPR target locus to create complex libraries of variants for protein engi...
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Article
Translation readthrough mitigation
Translation termination sequences are occasionally bypassed by the ribosome and the resulting proteins can be detrimental to the cell; here it is shown that cells can prevent such proteins from accumulating th...