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    Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells

    Recruiting a hyperactive cytidine deaminase via the guide RNA to dCas9 allows for the introduction of diverse point mutations at the CRISPR target locus to create complex libraries of variants for protein engi...

    Gaelen T Hess, Laure Frésard, Kyuho Han, Cameron H Lee, Amy Li… in Nature Methods (2016)