168 Result(s)

Article

Sonodynamic and sonomechanical effect on cellular stemness and extracellular physicochemical environment to potentiate chemotherapy

Hypoxia-activated prodrug (HAP) is a promising candidate for highly tumor-specific chemotherapy. However, the oxygenation heterogeneity and dense extracellular matrix (ECM) of tumor, as well as the potential r...

Danli Sheng, Tianzhi Liu, Lang Qian, Jufeng Chen, Yi Wei… in Journal of Nanobiotechnology (2024)

Article

N6-methyladenosine-driven miR-143/145-KLF4 circuit orchestrates the phenotypic switch of pulmonary artery smooth muscle cells

Pulmonary hypertension (PH) is characterized by vascular remodeling predominantly driven by a phenotypic switching in pulmonary artery smooth muscle cells (PASMCs). However, the underlying mechanisms for this ...

Kang Kang, Chuannan Sun, Hui Li, **aojia Liu… in Cellular and Molecular Life Sciences (2024)

Article

Correction: Characteristics and evaluation of C1 posterior arch variation for transpedicular screw placement between patients with and without basilar invagination

Lu-** Zhou, Chen-Hao Zhao, Zhi-Gang Zhang, ** Shang… in European Spine Journal (2024)

Article

Inadequate linear catch-up growth in children born small for gestational age: Influencing factors and underlying mechanisms

A minority of children born small for gestational age (SGA) may experience catch-up growth failure and remain short in adulthood. However, the underlying causes and mechanisms of this phenomenon are not yet fu...

Anran Tian, Fucheng Meng, Sujuan Li… in Reviews in Endocrine and Metabolic Disorde… (2024)

Article

Axillary lymph node metastasis in pure mucinous carcinoma of breast: clinicopathologic and ultrasonographic features

The purpose of this research is to study the sonographic and clinicopathologic characteristics that associate with axillary lymph node metastasis (ALNM) for pure mucinous carcinoma of breast (PMBC).

Na Li, Jia-Wei Li, Yu Qian, Ya-**g Liu, **u-Zhu Qi, Ya-Ling Chen… in BMC Medical Imaging (2024)

Article

Initiating PeriCBD to probe perinatal influences on neurodevelopment during 3–10 years in China

Adverse perinatal factors can interfere with the normal development of the brain, potentially resulting in long-term effects on the comprehensive development of children. Presently, the understanding of cognit...

Yin-Shan Wang, Xue-Ting Su, Li Ke, Qing-Hua He, Da Chang, **g**g Nie… in Scientific Data (2024)

Article

FGD1-related Aarskog–Scott syndrome: Identification of four novel variations and a literature review of clinical and molecular aspects

Patients with Aarskog–Scott syndrome (AAS) have short stature, facial anomalies, skeletal deformities, and genitourinary malformations. FYVE, RhoGEF, and PH domain-containing 1 (FGD1) is the only known causative ...

Sujuan Li, Anran Tian, Yu Wen, Wei Gu, Wei Li… in European Journal of Pediatrics (2024)

Article

Structural bases of inhibitory mechanism of Ca_V1.2 channel inhibitors

The voltage-gated calcium channel Ca_V1.2 is essential for cardiac and vessel smooth muscle contractility and brain function. Accumulating evidence demonstrates that malfunctions of Ca_V1.2 are involved in brain an...

Yiqing Wei, Zhuoya Yu, Lili Wang, **ao**g Li, Na Li, Qinru Bai… in Nature Communications (2024)

Article

A midbrain GABAergic circuit constrains wakefulness in a mouse model of stress

Enhancement of wakefulness is a prerequisite for adaptive behaviors to cope with acute stress, but hyperarousal is associated with impaired behavioral performance. Although the neural circuitries promoting wak...

Shuancheng Ren, Cai Zhang, Faguo Yue, **xiang Tang, Wei Zhang… in Nature Communications (2024)

Article

Diagnostic value of serum COMP and ADAMTS7 for intervertebral disc degeneration

Intervertebral disc degeneration (IVDD) is a major cause of morbidity and disability. Our study aimed to investigate the potential of cartilage oligomeric matrix protein (COMP) and ADAMTS7 (A disintegrin and m...

**g-Yu Ding, Xu Yan, Ren-Jie Zhang, Hua-Qing Zhang… in European Journal of Medical Research (2024)

Article

Boundedness and Convergence of Mini-batch Gradient Method with Cyclic Dropconnect and Penalty

Dropout is perhaps the most popular regularization method for deep learning. Due to the stochastic nature of the Dropout mechanism, the convergence analysis of Dropout learning is challenging and the existing ...

Junling **g, Cai **hang, Huisheng Zhang, Wenxia Zhang in Neural Processing Letters (2024)

Article

Eclectic flavor group ∆(27) ⋊ S₃ and lepton model building

We have performed a systematical study of the eclectic flavor group ∆(27) ⋊ S₃ which is the extension of the traditional flavor symmetry ∆(27) by the finite modular symmetry S₃. Consistency between ∆(27) and S₃ r...

Cai-Chang Li, Gui-Jun Ding in Journal of High Energy Physics (2024)

Article

Author Correction: Perioperative toripalimab and chemotherapy in locally advanced gastric or gastro-esophageal junction cancer: a randomized phase 2 trial

Shu-Qiang Yuan, Run-Cong Nie, Ying **, Cheng-Cai Liang, Yuan-Fang Li… in Nature Medicine (2024)

Article

Selective activator of human ClpP triggers cell cycle arrest to inhibit lung squamous cell carcinoma

Chemo-activation of mitochondrial ClpP exhibits promising anticancer properties. However, we are currently unaware of any studies using selective and potent ClpP activators in lung squamous cell carcinoma. In ...

Lin-Lin Zhou, Tao Zhang, Yun Xue, Chuan Yue, Yihui Pan… in Nature Communications (2023)

Article

A carrier-free supramolecular nano-twin-drug for overcoming irinotecan-resistance and enhancing efficacy against colorectal cancer

Irinotecan (Ir) is commonly employed as a first-line chemotherapeutic treatment for colorectal cancer (CRC). However, tremendous impediments remain to be addressed to surmount drug resistance and ameliorate ad...

Miaomiao Yuan, Tong Chen, Lu **, Peng Zhang, Luoyijun **e… in Journal of Nanobiotechnology (2023)

Article

Ab-initio simulations of coherent phonon-induced pum** of carriers in zirconium pentatelluride

Laser-driven coherent phonons can act as modulated strain fields and modify the adiabatic ground state topology of quantum materials. Here we use time-dependent first-principles and effective model calculation...

Tao Jiang, Peter P. Orth, Liang Luo, Lin-Lin Wang, Feng Zhang… in Communications Physics (2023)

Article

CD24⁺LCN2⁺ liver progenitor cells in ductular reaction contributed to macrophage inflammatory responses in chronic liver injury

CD24⁺CK19⁺/CD24⁺SOX9⁺ resident liver cells are activated and expanded after chronic liver injury in a ductular reaction. However, the sources and functions of these cells in liver damage remain disputed.

Wei-Jian Huang, Bi-Jun Qiu, **ao-Shu Qi, Cai-Yang Chen, Wen-Ming Liu… in Cell & Bioscience (2023)

Article

Efficacy and Safety of Triptorelin 3-Month Formulation in Chinese Children with Central Precocious Puberty: A Phase 3, Open-Label, Single-Arm Study

Triptorelin is available as 1- and 3-month prolonged-release (PR) formulations; at the time of the study, only the former was approved for central precocious puberty (CPP) in China. This study assessed the eff...

** Luo, Cai Zhang, Yu Yang, Xu Xu, **nran Cheng, Haiyan Wei… in Advances in Therapy (2023)

Article

Risk factors of peripheral venous catheter-related complication and infection in children with bronchopneumonia

To investigate the risk factors associated with the peripheral venous catheter-related complication and infection in children with bronchopneumonia.

Hong-mei Li, Li-li Wan, Cai-xiang **, Guo-ying Zhang, Hui Yang… in BMC Infectious Diseases (2023)

Article

Anlotinib affects systemic lipid metabolism and induces lipid accumulation in human lung cancer cells

Anlotinib has demonstrated encouraging clinical outcomes in the treatment of lung cancer, soft tissue sarcoma and thyroid carcinoma. Several clinical studies have shown a relationship between anlotinib treatme...

Zhongling Zhu, Shan Xu, **g Ren, Teng Jiang, Cai Zhang… in Lipids in Health and Disease (2023)