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14 Result(s)

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  1. Article

    Potent antitumor activity of Oct4 and hypoxia dual-regulated oncolytic adenovirus against bladder cancer

    Most solid tumors undergo hypoxia, leading to rapid cell division, metastasis and expansion of a cell population with hallmarks of cancer stem cells (CSCs). Tumor-selective replication of oncolytic adenoviruse...

    C-S Lu, J-L Hsieh, C-Y Lin, H-W Tsai, B-H Su, G-S Shieh, Y-C Su, C-H Lee… in Gene Therapy (2015)

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  2. Article

    Combination of vinblastine and oncolytic herpes simplex virus vector expressing IL-12 therapy increases antitumor and antiangiogenic effects in prostate cancer models

    Oncolytic herpes simplex virus (oHSV)-1-based vectors selectively replicate in tumor cells causing direct killing, that is, oncolysis, while sparing normal cells. The oHSVs are promising anticancer agents, but...

    B J Passer, T Cheema, S Wu, C-l Wu, S D Rabkin, R L Martuza in Cancer Gene Therapy (2013)

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    Article

    Assessing prostate cancer growth with citrate measured by intact tissue proton magnetic resonance spectroscopy

    Annual PSA tests have led to a significant increase in the number of prostate cancer (PCa) cases diagnosed. This increased incidence has led to overtreatment of many patients, as current pathology often cannot...

    R Dittrich, J Kurth, E A Decelle, E M DeFeo… in Prostate Cancer and Prostatic Diseases (2012)

  4. No Access

    Article

    Suppression of collagen-induced arthritis by intra-articular lentiviral vector-mediated delivery of Toll-like receptor 7 short hairpin RNA gene

    Knockdown of Toll-like receptors (TLRs) is a novel therapeutic strategy in treating patients with rheumatoid arthritis (RA). We examined the effects of lentiviral vector-mediated delivery of TLR7 short hairpin...

    S-Y Chen, A-L Shiau, Y-T Li, Y-S Lin, C-H Lee, C-L Wu, C-R Wang in Gene Therapy (2012)

  5. No Access

    Article

    Intra-articular lentivirus-mediated delivery of galectin-3 shRNA and galectin-1 gene ameliorates collagen-induced arthritis

    Different members of the galectin family may have inhibitory or stimulatory roles in controlling immune responses and regulating inflammatory reactions in autoimmune diseases such as rheumatoid arthritis (RA)....

    C-R Wang, A-L Shiau, S-Y Chen, Z-S Cheng, Y-T Li, C-H Lee, Y-T Yo, C-W Lo… in Gene Therapy (2010)

  6. No Access

    Article

    Enhancement of antitumor activity of gammaretrovirus carrying IL-12 gene through genetic modification of envelope targeting HER2 receptor: a promising strategy for bladder cancer therapy

    The objective of this study was to develop an HER2-targeted, envelope-modified Moloney murine leukemia virus (MoMLV)-based gammaretroviral vector carrying interleukin (IL)-12 gene for bladder cancer therapy. It d...

    Y-S Tsai, A-L Shiau, Y-F Chen, H-T Tsai, T-S Tzai, C-L Wu in Cancer Gene Therapy (2010)

  7. No Access

    Article

    Analysis of genetically engineered oncolytic herpes simplex viruses in human prostate cancer organotypic cultures

    Oncolytic herpes simplex viruses type 1 (oHSVs) such as G47Δ and G207 are genetically engineered for selective replication competence in cancer cells. Several factors can influence the overall effectiveness of...

    B J Passer, C-l Wu, S Wu, S D Rabkin, R L Martuza in Gene Therapy (2009)

  8. No Access

    Article

    Conditionally replicating E1B-deleted adenovirus driven by the squamous cell carcinoma antigen 2 promoter for uterine cervical cancer therapy

    Cervical cancer is the second most common type of malignant tumor among women worldwide. When the disease is confined locally, it can be controlled with surgical resection and radiotherapy. However, patients w...

    K-F Hsu, C-L Wu, S-C Huang, J-L Hsieh, Y-S Huang, Y-F Chen, M-R Shen… in Cancer Gene Therapy (2008)

  9. No Access

    Article

    Coexpression of Flt3 ligand and GM-CSF genes modulates immune responses induced by HER2/neu DNA vaccine

    DNA vaccine and dendritic cells (DCs)-based vaccine have emerged as promising strategies for cancer immunotherapy. Fms-like tyrosine kinase 3-ligand (Flt3L) and granulocyte–macrophage-colony-stimulating factor...

    Y-T Yo, K-F Hsu, G-S Shieh, C-W Lo, C-C Chang, C-L Wu, A-L Shiau in Cancer Gene Therapy (2007)

  10. Article

    Open Access

    Constitutive activation of STAT3 and STAT5 is present in the majority of nasopharyngeal carcinoma and correlates with better prognosis

    Constitutively activated signal transducers and activators of transcription (STAT) factors, in particular STAT1, STAT3 and STAT5, have been demonstrated in a variety of human tumours and cancer cell lines. How...

    J-R Hsiao, Y-T **, S-T Tsai, A-L Shiau, C-L Wu, W-C Su in British Journal of Cancer (2003)

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  11. Article

    Open Access

    Gene therapy for bladder cancer using E1B-55 kD-deleted adenovirus in combination with adenoviral vector encoding plasminogen kringles 1–5

    Mutations or loss of heterozygosity of p53 are detected in approximately 50% of bladder cancers. E1B-55 kD-deleted adenovirus has been shown to kill tumour cells with defective p53 function while sparing norma...

    J-L Hsieh, C-L Wu, M-D Lai, C-H Lee, C-S Tsai, A-L Shiau in British Journal of Cancer (2003)

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  12. No Access

    Article

    Gene-gun particle with pro-opiomelanocortin cDNA produces analgesia against formalin-induced pain in rats

    Endogenous opioid peptides play an essential role in the intrinsic modulation and control of inflammatory pain, and could be therapeutically useful. These opioid peptides are synthesized as parts of larger pre...

    C-Y Lu, A-K Chou, C-L Wu, C-H Yang, J-T Chen, P-C Wu, S-H Lin, R Muhammad… in Gene Therapy (2002)

  13. No Access

    Article

    Retrovirus-mediated transfer of prothymosin gene inhibits tumor growth and prolongs survival in murine bladder cancer

    To explore the potential use of prothymosin α(ProT), a putative thymic hormone, in gene therapy for bladder cancer, we generated a replication-defective recombinant retroviral vector encoding ProT and tested i...

    A-L Shiau, P-R Lin, M-Y Chang, C-L Wu in Gene Therapy (2001)

  14. No Access

    Article

    Provision of positive and negative selections in retroviral vectors containing the cytosine deaminase gene

    The E. coli cytosine deaminase (CD) provides a negative selection system for suicide gene therapy as CD transfectants are eliminated following 5-fluorocytosine (5FC) treatment. Here we report a positive select...

    A-L Shiau, H-M Yang, P Wu, C-L Wu in Gene Therapy (1998)