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Article
Open AccessAddressing COVID-19 challenges in a randomised controlled trial on exercise interventions in a high-risk population
The coronavirus disease 2019 (COVID-19) pandemic is a threat to ongoing clinical trials necessitating regular face-to-face, in-person meetings, particularly in participants with a high risk of complications. G...
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Article
Open AccessMulticentre phase II trial of trastuzumab and capecitabine in patients with HER2 overexpressing metastatic pancreatic cancer
New therapeutic options for metastatic pancreatic cancer are urgently needed. In pancreatic cancer, overexpression of the epidermal growth factor receptor 2 (HER2) has been reported in up to 45%. This multicen...
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Article
Open AccessSafety and tolerability of virucidal hand rubs: a randomized, double-blind, cross-over trial
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Article
Open AccessDuration of adjuvant chemotherapy for breast cancer: a joint analysis of two randomised trials investigating three versus six courses of CMF
Cyclophosphamide, methotrexate and fluorouracil adjuvant combination chemotherapy for breast cancer is currently used for the duration of six monthly courses. We performed a joint analysis of two studies on th...
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Article
Open AccessModelling the effects of standard prognostic factors in node-positive breast cancer
Prognostic models that predict the clinical course of a breast cancer patient are important in oncology. We propose an approach to constructing such models based on fractional polynomials in which useful trans...
