10 Result(s)

Article

Upregulation of alpha cell glucagon-like peptide 1 (GLP-1) in Psammomys obesus—an adaptive response to hyperglycaemia?

The hormone glucagon-like peptide 1 (GLP-1) is released in response to a meal from the intestinal L-cells, where it is processed from proglucagon by the proconvertase (PC)1/3. In contrast, in the adult islets ...

A. M. K. Hansen, T. B. Bödvarsdottir, D. N. E. Nordestgaard, R. S. Heller… in Diabetologia (2011)

Article

Treatment with a proton pump inhibitor improves glycaemic control in Psammomys obesus, a model of type 2 diabetes

Gastrin has been implicated in islet growth/neogenesis, and proton pump inhibitors (PPIs) have been shown to increase endogenous gastrin levels in animals and humans. Therefore, we investigated the effect of P...

T. B. Bödvarsdóttir, K. D. Hove, C. F. Gotfredsen, L. Pridal, A. Vaag… in Diabetologia (2010)

Article

Reduction of beta cell mass: partial insulin secretory compensation from the residual beta cell population in the nicotinamide–streptozotocin Göttingen minipig after oral glucose in vivo and in the perfused pancreas

A progressive loss of beta cell function and mass are important contributory factors in the development and progression of type 2 diabetes. The aim of this study was to evaluate the effects of a primary reduct...

M. O. Larsen, B. Rolin, C. F. Gotfredsen, R. D. Carr, J. J. Holst in Diabetologia (2004)

Article

40^th EASD Annual Meeting of the European Association for the Study of Diabetes

M. Veitenhansl, K. Stegner, F.-X. Hierl, C. Dieterle, H. Feldmeier, B. Gutt… in Diabetologia (2004)

Article

Changes in expression of IL-1β influenced proteins in transplanted islets during development of diabetes in diabetes-prone BB rats

Type 1 diabetes mellitus is a multifactorial autoimmune disease characterised by selective destruction of beta cells in the islets of Langerhans. We have previously shown that IL-1β modulates beta cell functio...

T. Sparre, U. Bjerre Christensen, C. F. Gotfredsen, P. Mose Larsen… in Diabetologia (2004)

Article

Loss of beta-cell mass leads to a reduction of pulse mass with normal periodicity, regularity and entrainment of pulsatile insulin secretion in Göttingen minipigs

M. O. Larsen PhD, C. F. Gotfredsen, M. Wilken, R. D. Carr, N. Pørksen… in Diabetologia (2004)

Article

Loss of beta-cell mass leads to a reduction of pulse mass with normal periodicity, regularity and entrainment of pulsatile insulin secretion in Göttingen minipigs

Type 2 diabetes is associated with impaired insulin action and secretion, including disturbed pulsatile release. Impaired pulsatility has been related to impaired insulin action, thus providing a possible link...

M. O. Larsen PhD, C. F. Gotfredsen, M. Wilken, R. D. Carr, N. Pørksen… in Diabetologia (2003)

Article

35th Annual Meeting of the European Association for the Study of Diabetes

A. Melander, J. Olsson, G. Lindberg, A. Salzman, T. Howard, P. Stang… in Diabetologia (1999)

Article

Reduction of diabetes incidence of BB Wistar rats by early prophylactic insulin treatment of diabetes-prone animals

A group of 36 diabetes-prone BB Wistar rats were given prophylactic insulin treatment with heat-treated bovine ultralente insulin (15 IU · kg⁻¹ · day⁻¹) from 50 to 142 days of age. The incidence of Type 1 (insuli...

C. F. Gotfredsen, K. Buschard, E. K. Frandsen in Diabetologia (1985)

Article

Dynamics of sulfonylurea-induced insulin release from the isolated perfused rat pancreas

In the isolated perfused rat pancreas various sulfonylurea drugs were tested with a basal glucose level of 1 mg/ml in the perfusion buffer and were found to cause a biphasic insulin response. NOVO CS 476, a ne...

C. F. Gotfredsen in Diabetologia (1976)