Injury Models of the Central Nervous System
Methods and Protocols
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Article
Temporal-Specific Sex and Injury-Dependent Changes on Neurogranin-Associated Synaptic Signaling After Controlled Cortical Impact in Rats
Extensive effort has been made to study the role of synaptic deficits in cognitive impairment after traumatic brain injury (TBI). Neurogranin (Ng) is a calcium-sensitive calmodulin (CaM)–binding protein essent...
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Article
Open AccessAbcc8 (sulfonylurea receptor-1) knockout mice exhibit reduced axonal injury, cytotoxic edema and cognitive dysfunction vs. wild-type in a cecal ligation and puncture model of sepsis
Sepsis-associated brain injury (SABI) is characterized by an acute deterioration of mental status resulting in cognitive impairment and acquisition of new and persistent functional limitations in sepsis surviv...
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Article
Open AccessMicroglial–oligodendrocyte interactions in myelination and neurological function recovery after traumatic brain injury
Differential microglial inflammatory responses play a role in regulation of differentiation and maturation of oligodendrocytes (OLs) in brain white matter. How microglia–OL crosstalk is altered by traumatic br...
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Article
Open AccessMicroglia-specific deletion of histone deacetylase 3 promotes inflammation resolution, white matter integrity, and functional recovery in a mouse model of traumatic brain injury
Histone deacetylases (HDACs) are believed to exacerbate traumatic brain injury (TBI) based on studies using pan-HDAC inhibitors. However, the HDAC isoform responsible for the detrimental effects and the cell t...
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Article
Reductions in Synaptic Vesicle Glycoprotein 2 Isoforms in the Cortex and Hippocampus in a Rat Model of Traumatic Brain Injury
Traumatic brain injury (TBI) can produce lasting cognitive, emotional, and somatic difficulties that can impact quality of life for patients living with an injury. Impaired hippocampal function and synaptic al...
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Chapter
The Controlled Cortical Impact Model of Experimental Brain Trauma: Overview, Research Applications, and Protocol
Controlled cortical impact (CCI) is a commonly used and highly-regarded model of brain trauma that uses a pneumatically- or electromagnetically-driven piston to induce reproducible and well-controlled injury. ...
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Article
Open AccessAcute Physiology and Neurologic Outcomes after Brain Injury in SCOP/PHLPP1 KO Mice
Suprachiasmatic nucleus circadian oscillatory protein (SCOP) (a.k.a. PHLPP1) regulates long-term memory consolidation in the brain. Using a mouse model of controlled cortical impact (CCI) we tested if (1) brai...
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Article
Effects of DHA on Hippocampal Autophagy and Lysosome Function After Traumatic Brain Injury
Traumatic brain injury (TBI) triggers endoplasmic reticulum (ER) stress and impairs autophagic clearance of damaged organelles and toxic macromolecules. In this study, we investigated the effects of the post-T...
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Protocol
Controlled Cortical Impact for Modeling Traumatic Brain Injury in Animals
Controlled cortical impact (CCI) is one of the most common experimental models of traumatic brain injury (TBI). The original CCI device used a pneumatic piston to induce TBI in ferrets; CCI has since been adap...
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Article
Structural imaging of mild traumatic brain injury may not be enough: overview of functional and metabolic imaging of mild traumatic brain injury
A majority of patients with traumatic brain injury (TBI) present as mild injury with no findings on conventional clinical imaging methods. Due to this difficulty of imaging assessment on mild TBI patients, the...
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Book
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Article
ER Stress and Effects of DHA as an ER Stress Inhibitor
The endoplasmic reticulum (ER) functions in the synthesis, folding, modification, and transport of newly synthesized transmembrane and secretory proteins. The ER also has important roles in the storage of intr...
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Article
Morris water maze function and histologic characterization of two age-at-injury experimental models of controlled cortical impact in the immature rat
Controlled cortical impact (CCI) is commonly used in adult animals to study focal traumatic brain injury (TBI). Our study aims to further study injury mechanisms in children and variable models of pathology in...
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Protocol
Vestibular Assessments Following Traumatic Brain Injury
Motor function is a common deficit in patients who have experienced a traumatic brain injury (TBI). These deficits include difficulties with balance, increased dizziness, reductions in strength, and fine motor...
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Protocol
Neurobehavioral Assessments of Traumatic Brain Injury
Assessment of neurologic deficit following traumatic brain injury (TBI) is integral to effective evaluation of injury severity, course, and recovery. Paradigms that involve training regimens can be difficult t...
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Protocol
Controlled Cortical Impact Injury Model
Controlled focal mechanical cortical deformations in rodents have been widely used to model histological, physiological, neurochemical, and functional aspects of human traumatic brain injury. The most common t...
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Chapter and Conference Paper
Effect of Local Cooling (15° C for 24 Hours) with the Chillerpad™ after Traumatic Brain Injury in the Nonhuman Primate
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Chapter
Neurotransmitter and Growth Factor Alterations in Functional Deficits and Recovery Following Traumatic Brain Injury
It is well established that traumatic brain injury (TBI), regardless of level of severity, may result in significant disability due to its attendant neurobehavioral deficits. Neuropsychological studies of outc...
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Chapter
Cell Signaling: Serine/Threonine Protein Kinases and Traumatic Brain Injury
Traumatic brain injury (TBI) is a complex interaction of primary and secondary processes that may require days to evolve. Injury processes are related to the magnitude and type of TBI and the resulting systemi...
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Chapter
Muscarinic Receptor Blockade Reveals Changes in Cholinergic Function in Two Models of Traumatic Brain Injury (TBI)
Along with other laboratories, we have provided data suggesting that abnormal agonistreceptor interactions produce sublethal excitotoxic changes in neural function that contribute to traumatic brain injury (TB...
