7 Result(s)
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Article
Open AccessThe Musashi RNA-binding proteins in female cancers: insights on molecular mechanisms and therapeutic relevance
RNA-binding proteins have increasingly been identified as important regulators of gene expression given their ability to bind distinct RNA sequences and regulate their fate. Mounting evidence suggests that RNA...
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Article
Open AccessCharacterization and dynamics of the soluble immunological microenvironment in melanoma patients undergoing radiotherapy
Malignant melanoma constitutes an aggressive tumor of the skin, the pathogenesis of which is influenced by immunological processes. In this context, the influence of radiotherapy (RT) on inflammatory markers h...
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Article
Open AccessSyndecan-1 is a novel molecular marker for triple negative inflammatory breast cancer and modulates the cancer stem cell phenotype via the IL-6/STAT3, Notch and EGFR signaling pathways
Inflammatory breast cancer (IBC), a particularly aggressive form of breast cancer, is characterized by cancer stem cell (CSC) phenotype. Due to a lack of targeted therapies, the identification of molecular mar...
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Article
Open AccessInfluence of secreted frizzled receptor protein 1 (SFRP1) on neoadjuvant chemotherapy in triple negative breast cancer does not rely on WNT signaling
Triple negative breast cancer (TNBC) is characterized by lack of expression of both estrogen and progesterone receptor as well as lack of overexpression or amplification of HER2. Despite an increased probabili...
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Article
Open AccessAssociation of telomerase activity with radio- and chemosensitivity of neuroblastomas
Telomerase activity compensates shortening of telomeres during cell division and enables cancer cells to escape senescent processes. It is also supposed, that telomerase is associated with radio- and chemoresi...
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Open AccessSelective regain of egfr gene copies in CD44+/CD24-/lowbreast cancer cellular model MDA-MB-468
Increased transcription of oncogenes like the epidermal growth factor receptor (EGFR) is frequently caused by amplification of the whole gene or at least of regulatory sequences. Aim of this study was to pinpo...
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Multicentric investigation of ionising radiation-induced cell death as a predictive parameter of individual radiosensitivity
In the present study, the predictive value of ionising radiation (IR)-induced cell death was tested in peripheral blood lymphocytes (PBLs) and their corresponding Epstein-Barr virus-transformed lymphoblastoid ...
