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Article
ModiBodies: A computational method for modifying nanobodies in nanobody-antigen complexes to improve binding affinity and specificity
Nanobodies are special derivatives of antibodies, which consist of single domain fragments. They have become of considerable interest as next-generation biotechnological tools for antigen recognition. They can...
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Article
Open AccessOncogenic G12D mutation alters local conformations and dynamics of K-Ras
K-Ras is the most frequently mutated oncoprotein in human cancers, and G12D is its most prevalent mutation. To understand how G12D mutation impacts K-Ras function, we need to understand how it alters the regul...
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Article
Reducing Virulence and Biofilm of Pseudomonas aeruginosa by Potential Quorum Sensing Inhibitor Carotenoid: Zeaxanthin
Pseudomonas aeruginosa can regulate its virulence gene expressions by using a signal system called quorum sensing. It is known that inhibition of quorum sensing can block biofilm formatio...
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Article
Open AccessIntrinsic K-Ras dynamics: A novel molecular dynamics data analysis method shows causality between residue pair motions
K-Ras is the most frequently mutated oncogene in human cancers, but there are still no drugs that directly target it in the clinic. Recent studies utilizing dynamics information show promising results for sele...
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Chapter
Molecular Aspects of Rubber Elasticity
In this paper, the molecular aspects of rubber-like solids are reviewed. The elasticity of the single polymer chain, which is the basic unit of the elastomeric solid, is discussed first. The structure of the n...
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Article
Free radical crosslinking of unsaturated bacterial polyesters obtained from soybean oily acids
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Chapter
Determination of Cross-Link Density in Amorphous Networks by Stress-Strain-Swelling Experiments
The degree of cross-linking in an amorphous elastomeric network is related to the shear modulus which may be determined either by stress-strain experiments or by equilibrium swelling measurements in a solvent....
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Chapter
Anisotropy of Rubber Networks Crosslinked in States of Strain
Anisotropy of amorphous polymer networks crosslinked first in the isotropic state and subsequently in the stretched state is analyzed using the junction constraint theory. According to the theory, the anisotro...
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Chapter
The Scattering of Light by Swollen Networks
Swollen networks scatter more light than solutions of linear molecules of the same concentration. This occurs because of the concentration fluctuations associated with the variation of the local degree of swel...
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Chapter
Polymers and Rubber Elasticity: Thermodynamics of Large Dimensional Changes in Amorphous Systems
Polymeric molecules constitute a large fraction of the living material They may be in the form of a single macromolecule dissolved in a suitable fluid, or may exist as a three dimensional topological network s...
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Chapter
Calculation of Molecular Deformation and Orientation in Elastomers Using the Flory Network Model
The molecular model of an elastomeric network with local intermolecular correlations, given by Flory, is used to calculate the components of the molecular deformation tensor and molecular orientation. Effects ...