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Engineered materials for in vivo delivery of genome-editing machinery

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  1. Article

    Open Access

    ssAAVs containing cassettes encoding SaCas9 and guides targeting hepatitis B virus inactivate replication of the virus in cultured cells

    Management of infection with hepatitis B virus (HBV) remains a global health problem. Persistence of stable covalently closed circular DNA (cccDNA) during HBV replication is responsible for modest curative eff...

    Tristan Scott, Buhle Moyo, Samantha Nicholson, Mohube Betty Maepa… in Scientific Reports (2017)

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