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Open AccessThe Concept of Stroma AReactive Invasion Front Areas (SARIFA) as a new prognostic biomarker for lipid-driven cancers holds true in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is a ‘difficult-to-treat’ entity. To forecast its prognosis, we introduced a new biomarker, SARIFA (stroma areactive invasion front areas), which are areas at the tumour...
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Open AccessDeep learning for dual detection of microsatellite instability and POLE mutations in colorectal cancer histopathology
In the spectrum of colorectal tumors, microsatellite-stable (MSS) tumors with DNA polymerase ε (POLE) mutations exhibit a hypermutated profile, holding the potential to respond to immunotherapy similarly to their...
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Open AccessStroma AReactive Invasion Front Areas (SARIFA) improves prognostic risk stratification of perioperative chemotherapy treated oesophagogastric cancer patients from the MAGIC and the ST03 trial
Tumour-associated fat cells without desmoplastic stroma reaction at the invasion front (Stroma AReactive Invasion Front Areas (SARIFA)) is a prognostic biomarker in gastric and colon cancer. The clinical utili...
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Open AccessNovel biomarker SARIFA in colorectal cancer: highly prognostic, not genetically driven and histologic indicator of a distinct tumor biology
SARIFA (Stroma AReactive Invasion Front Areas) has recently emerged as a promising histopathological biomarker for colon and gastric cancer. To elucidate the underlying tumor biology, we assessed SARIFA-status...
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Open AccessSARIFA as a new histopathological biomarker is associated with adverse clinicopathological characteristics, tumor-promoting fatty-acid metabolism, and might predict a metastatic pattern in pT3a prostate cancer
Recently, we introduced Stroma-AReactive-Invasion-Front-Areas (SARIFA) as a novel hematoxylin–eosin (H&E)-based histopathologic prognostic biomarker for various gastrointestinal cancers, closely related to lip...
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Open AccessStroma AReactive Invasion Front Areas (SARIFA) proves prognostic relevance in gastric carcinoma and is based on a tumor–adipocyte interaction indicating an altered immune response
Recently, we presented Stroma AReactive Invasion Front Areas (SARIFA) as a new histomorphologic negative prognostic biomarker in gastric cancer. It is defined as direct contact between tumor cells and fat cell...
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Article
NGS-basierte Molekulargenetik der Leukämie – ein leistungsfähiger und dezentraler Lösungsansatz
Die Diagnostik der akuten myeloischen Leukämie (AML) und des myelodysplastischen Syndroms (MDS), die ursprünglich primär auf einer morphologischen Beurteilung beruhte, integriert nun immer mehr unterschiedlich...
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Open AccessThe impact of progredient vessel and tissue stiffening for the development of metabolic syndrome
Established risk factors for the metabolic syndrome as diabetes and arterial hypertension are believed to be the cause of arteriosclerosis and subsequently following diseases like coronary heart disease, apopl...
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Article
Open AccessAlterations of circulating lymphocyte subsets in patients with colorectal carcinoma
Cellular immune response to cancer is known to be of great importance for tumor control. Moreover, solid tumors influence circulating lymphocytes, which has been shown for several types of cancer. In our prosp...
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Open AccessOrgan manifestations of COVID-19: what have we learned so far (not only) from autopsies?
The use of autopsies in medicine has been declining. The COVID-19 pandemic has documented and rejuvenated the importance of autopsies as a tool of modern medicine. In this review, we discuss the various autops...
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Open AccessAdrenal tropism of SARS-CoV-2 and adrenal findings in a post-mortem case series of patients with severe fatal COVID-19
Progressive respiratory failure and hyperinflammatory response is the primary cause of death in the coronavirus disease 2019 (COVID-19) pandemic. Despite mounting evidence of disruption of the hypothalamus-pit...
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Open AccessContamination of personal protective equipment during COVID-19 autopsies
Confronted with an emerging infectious disease at the beginning of the COVID-19 pandemic, the medical community faced concerns regarding the safety of autopsies on those who died of the disease. This attitude ...
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Open AccessCorrection to: Tumor proportion in colon cancer: results from a semiautomatic image analysis approach
A Correction to this paper has been published: https://doi.org/10.1007/s00428-021-03079-5
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Open AccessCan low autopsy rates be increased? Yes, we can! Should postmortem examinations in oncology be performed? Yes, we should! A postmortem analysis of oncological cases
Ever declining autopsy rates have been a concern of pathologists as well as clinicians for decades. Notably, in the field of oncology, data on autopsies and discrepancies between clinical and autoptic diagnose...
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Open AccessNumber of pathologists in Germany: comparison with European countries, USA, and Canada
The rapid development of pathology is in contrast to a shortage of qualified staff. The aims of the present study are to compile basic information on the numbers of German physicians in pathology and to compar...
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COVID-19: what the clinician should know about post-mortem findings
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Open AccessYAP1-NUTM1 Gene Fusion in Porocarcinoma of the External Auditory Canal
Gene fusions involving the NUTM1 gene (NUT) represent defining genetic markers of a highly aggressive carcinoma type with predilection for the midline structures of children and young adults, hence the original d...
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Article
Open AccessAlemtuzumab-associated diffuse alveolar damage – a case report
Identifying causes of alemtuzumab induced respiratory symptoms in Multiple Sclerosis (MS) patients is crucial.
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Open AccessTumor proportion in colon cancer: results from a semiautomatic image analysis approach
The tumor stroma ratio (TSR) is a promising prognostic biomarker in colon cancer, which could provide additional risk stratification for therapy adaption. The objective of our study was the investigation of th...
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Open AccessThe neuropathology of fatal encephalomyelitis in human Borna virus infection
After many years of controversy, there is now recent and solid evidence that classical Borna disease virus 1 (BoDV-1) can infect humans. On the basis of six brain autopsies, we provide the first systematic ove...
