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Overlap** genetic architecture between Parkinson disease and melanoma

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  1. Article

    Open Access

    Functional genomic analyses uncover APOE-mediated regulation of brain and cerebrospinal fluid beta-amyloid levels in Parkinson disease

    Alpha-synuclein is the main protein component of Lewy bodies, the pathological hallmark of Parkinson’s disease. However, genetic modifiers of cerebrospinal fluid (CSF) alpha-synuclein levels remain unknown. Th...

    Laura Ibanez, Jorge A. Bahena, Chengran Yang… in Acta Neuropathologica Communications (2020)

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  2. Article

    Open Access

    TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis

    Multiple sclerosis (MS) is an inflammatory, demyelinating, and neurodegenerative disease of the central nervous system (CNS) triggered by autoimmune mechanisms. Microglia are critical for the clearance of myel...

    Francesca Cignarella, Fabia Filipello, Bryan Bollman… in Acta Neuropathologica (2020)

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  3. Article

    Correction to: Overlap** genetic architecture between Parkinson disease and melanoma

    The original version of this article unfortunately contained a mistake. Supplementary Tables 3 and 4 are not available with the rest of the supplementary material available online.

    Umber Dube, Laura Ibanez, John P. Budde, Bruno A. Benitez… in Acta Neuropathologica (2020)

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  4. Article

    Open Access

    Clinically early-stage CSPα mutation carrier exhibits remarkable terminal stage neuronal pathology with minimal evidence of synaptic loss

    Autosomal dominant adult-onset neuronal ceroid lipofuscinosis (AD-ANCL) is a multisystem disease caused by mutations in the DNAJC5 gene. DNAJC5 encodes Cysteine String Protein-alpha (CSPα), a putative synaptic pr...

    Bruno A. Benitez, Nigel J. Cairns… in Acta Neuropathologica Communications (2015)

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