5 Result(s)
within
Brian H Chen
Gene Function
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Article
The trans-ancestral genomic architecture of glycemic traits
Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregate...
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Article
Open AccessNovel age-associated DNA methylation changes and epigenetic age acceleration in middle-aged African Americans and whites
African Americans (AAs) experience premature chronic health outcomes and longevity disparities consistent with an accelerated aging phenotype. DNA methylation (DNAm) levels at specific CpG positions are hallma...
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Article
Open AccessAnalysis of repeated leukocyte DNA methylation assessments reveals persistent epigenetic alterations after an incident myocardial infarction
Most research into myocardial infarctions (MIs) have focused on preventative efforts. For survivors, the occurrence of an MI represents a major clinical event that can have long-lasting consequences. There has...
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Article
Identification of common genetic variants controlling transcript isoform variation in human whole blood
Christopher O'Donnell and colleagues report a genome-wide screen for splicing quantitative trait loci (sQTLs) in 5,257 human blood samples. They identify cis sQTLs affecting mRNA isoform variation for over 2,000 ...
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Article
A systematic heritability analysis of the human whole blood transcriptome
Genome-wide expressio n quantitative trait locus (eQTL) map** may reveal common genetic variants regulating gene expression. In addition to map** eQTLs, we systematically evaluated the heritability of the ...
