23 Result(s)
within
Bobbie-Jo M. Webb-Robertson
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Article
Open AccessProteogenomic characterization of difficult-to-treat breast cancer with tumor cells enriched through laser microdissection
Breast cancer (BC) is the most commonly diagnosed cancer and the leading cause of cancer death among women globally. Despite advances, there is considerable variation in clinical outcomes for patients with non...
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Open AccessA compendium of multi-omics data illuminating host responses to lethal human virus infections
Human infections caused by viral pathogens trigger a complex gamut of host responses that limit disease, resolve infection, generate immunity, and contribute to severe disease or death. Here, we present experi...
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Open AccessRegulation of β-cell death by ADP-ribosylhydrolase ARH3 via lipid signaling in insulitis
Lipids are regulators of insulitis and β-cell death in type 1 diabetes development, but the underlying mechanisms are poorly understood. Here, we investigated how the islet lipid composition and downstream sig...
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Open AccessMap** microhabitats of lignocellulose decomposition by a microbial consortium
The leaf-cutter ant fungal garden ecosystem is a naturally evolved model system for efficient plant biomass degradation. Degradation processes mediated by the symbiotic fungus Leucoagaricus gongylophorus are diff...
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Open AccessEngineering transcriptional regulation of pentose metabolism in Rhodosporidium toruloides for improved conversion of xylose to bioproducts
Efficient conversion of pentose sugars remains a significant barrier to the replacement of petroleum-derived chemicals with plant biomass-derived bioproducts. While the oleaginous yeast Rhodosporidium toruloides ...
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Open AccessA genomic data archive from the Network for Pancreatic Organ donors with Diabetes
The Network for Pancreatic Organ donors with Diabetes (nPOD) is the largest biorepository of human pancreata and associated immune organs from donors with type 1 diabetes (T1D), maturity-onset diabetes of the ...
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Correction to: Targeted metabolomic analysis identifies increased serum levels of GABA and branched chain amino acids in canine diabetes
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Tutorial: best practices and considerations for mass-spectrometry-based protein biomarker discovery and validation
Mass-spectrometry-based proteomic analysis is a powerful approach for discovering new disease biomarkers. However, certain critical steps of study design such as cohort selection, evaluation of statistical pow...
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Interpreting the lipidome: bioinformatic approaches to embrace the complexity
Improvements in mass spectrometry (MS) technologies coupled with bioinformatics developments have allowed considerable advancement in the measurement and interpretation of lipidomics data in recent years. Sinc...
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Open AccessA resource of lipidomics and metabolomics data from individuals with undiagnosed diseases
Every year individuals experience symptoms that remain undiagnosed by healthcare providers. In the United States, these rare diseases are defined as a condition that affects fewer than 200,000 individuals. How...
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Open AccessFurther engineering of R. toruloides for the production of terpenes from lignocellulosic biomass
Mitigation of climate change requires that new routes for the production of fuels and chemicals be as oil-independent as possible. The microbial conversion of lignocellulosic feedstocks into terpene-based biof...
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Open AccessBetter understanding and prediction of antiviral peptides through primary and secondary structure feature importance
The emergence of viral epidemics throughout the world is of concern due to the scarcity of available effective antiviral therapeutics. The discovery of new antiviral therapies is imperative to address this cha...
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Open AccessNovel genetic risk factors influence progression of islet autoimmunity to type 1 diabetes
Type 1 diabetes arises from the autoimmune destruction of insulin-producing beta-cells of the pancreas, resulting in dependence on exogenously administered insulin to maintain glucose homeostasis. In this stud...
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Open AccessAn integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells
Interferon-α (IFNα), a type I interferon, is expressed in the islets of type 1 diabetic individuals, and its expression and signaling are regulated by T1D genetic risk variants and viral infections associated ...
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Open AccessAutomated mass spectrometry imaging of over 2000 proteins from tissue sections at 100-μm spatial resolution
Biological tissues exhibit complex spatial heterogeneity that directs the functions of multicellular organisms. Quantifying protein expression is essential for elucidating processes within complex biological a...
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Article
Assessment of the Utility of the Oral Fluid and Plasma Proteomes for Hydrocodone Exposure
Non-medical use and abuse of prescription opioids is a growing problem in both the civilian and military communities, with minimal technologies for detecting hydrocodone use. This study explored the proteomic ...
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The impact of proinflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes
The early stages of type 1 diabetes (T1D) are characterized by local autoimmune inflammation and progressive loss of insulin-producing pancreatic β cells. Here we show that exposure to proinflammatory cytokine...
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Bayesian Posterior Integration for Classification of Mass Spectrometry Data
High-throughput technologies currently have the capability to capture information at both global and targeted scales for the transcriptome, proteome, and metabolome, as well as determining functional aspects o...
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Article
Spectral signatures for the classification of microbial species using Raman spectra
In general, classification-based methods based on confocal Raman microscopy are focused on targeted studies under which the spectral libraries are collected under controlled instrument parameters, which facili...
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Open AccessVESPA: software to facilitate genomic annotation of prokaryotic organisms through integration of proteomic and transcriptomic data
The procedural aspects of genome sequencing and assembly have become relatively inexpensive, yet the full, accurate structural annotation of these genomes remains a challenge. Next-generation sequencing transc...
