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Article
Association of Promoter Methylation and Expression of Inflammatory Genes IL-6 and TNF-α with the Risk of Coronary Artery Disease in Diabetic and Obese Subjects among Asian Indians
The inflammatory cytokines such as interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-α) are considered as the most important contributors to the endothelial dysfunction in subjects with type 2 diabete...
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Article
Probing the epigenetic signatures in subjects with coronary artery disease
Depletion of S-adenosyl methionine and 5-methyltetrahydrofolate; and elevation of total plasma homocysteine were documented in CAD patients, which might modulate the gene-specific methylation status and alter the...
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Article
Dual Effect of IL-6 -174 G/C Polymorphism and Promoter Methylation in the Risk of Coronary Artery Disease Among South Indians
Inflammation plays an important role in the pathogenesis of atherosclerosis and coronary syndromes; moreover, various lines of evidence suggest that genetic factors do contribute to the risk of coronary artery...
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Chapter
Impact of Genetic and Epigenetic Factors on the Oxidative Stress in Cardiovascular Disease
Cardiovascular disease (CVD) is one of the most common causes of deaths globally. Oxidative stress is documented to be one of the potential risk factors for CVD. This review focuses on genetic and epigenetic f...
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Article
Machine learning algorithm-based risk prediction model of coronary artery disease
In view of high mortality associated with coronary artery disease (CAD), development of an early predicting tool will be beneficial in reducing the burden of the disease. The database comprising demographic, c...
