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Chapter
Human African Trypanosomiasis (HAT)
Human African Trypanosomiasis (HAT) found only in sub-Saharan Africa is caused by the parasite Trypanosoma brucei, which is transmitted by tsetse flies. Only two sub-species of T. brucei are pathogenic for humans...
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Chapter
Drug Donation Programmes in the Control and Elimination of NTDs
This chapter reviews the history and evolution of the medicine donation model that has been the mainstay of neglected tropical disease (NTD) control programmes since Merck & Co., Inc. made the decision to dona...
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Book
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Chapter
Onchocerciasis Part I
Onchocerciasis, also known as river blindness, is a dermic filariasis caused by the nematode Onchocerca volvulus. The disease is found in 30 African countries between latitudes 15°N and 14°S. About 20.9 million p...
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Chapter
Onchocerciasis Part 2: Elimination
The International Task Force for Disease Eradication (ITFDE) defines elimination as the reduction to zero of the incidence of infection caused by a disease specific pathogen in a defined geographic area, as a ...
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Article
Open AccessThe need for evidence-based strategies and tools for onchocerciasis elimination in Africa
In a recent article we discussed the feasibility of onchocerciasis elimination in Africa by 2025. We expressed concern that elimination may be impeded by failure to build on the lessons learned in the African ...
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Article
Open AccessIs onchocerciasis elimination in Africa feasible by 2025: a perspective based on lessons learnt from the African control programmes
Onchocerciasis is found predominantly in Africa where large scale vector control started in 1974. Registration and donation of ivermectin by Merck & Co in 1987 enabled mass treatment with ivermectin in all end...
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Chapter
Onchocerciasis
Onchocerciasis, a dermic filariasis, is caused by the nematode Onchocerca volvulus. The disease is found in 30 African countries between latitudes 15° N and 14° S. About 37 million people are infected, 500,000 of...
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Article
Open AccessWuchereria bancrofti transmission pattern in southern Mali prior to and following the institution of mass drug administration
The Global Programme to Eliminate Lymphatic Filariasis (GPELF) was launched in 2000 with the goal of stop** transmission of lymphatic filariasis (LF) through yearly mass drug administration (MDA). Although p...
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Article
Open AccessImpact of ivermectin on onchocerciasis transmission: assessing the empirical evidence that repeated ivermectin mass treatments may lead to elimination/eradication in West-Africa
The Onchocerciasis Control Program (OCP) in West Africa has been closed down at the end of 2002. All subsequent control will be transferred to the participating countries and will almost entirely be based on p...
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Article
Open AccessMacrofilaricides and onchocerciasis control, mathematical modelling of the prospects for elimination
In most endemic parts of the world, onchocerciasis (river blindness) control relies, or will soon rely, exclusively on mass treatment with the microfilaricide ivermectin. Worldwide eradication of the parasite ...
