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Article
FeSTGCN: A frequency-enhanced spatio-temporal graph convolutional network for traffic flow prediction under adaptive signal timing
Traffic flow prediction is the fundamental cornerstone of intelligent urban transportation systems. However, existing research has predominantly focused on exploring spatiotemporal dependencies within the spat...
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Article
Novel lncRNA Gm33149 modulates metastatic heterogeneity in melanoma by regulating the miR-5623-3p/Wnt axis via exosomal transfer
The high mortality rate associated with melanoma primarily results from metastasis and recurrence. However, the precise mechanisms driving these processes remain poorly understood. Intercellular communication ...
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Article
Open AccessGlobal fungal-host interactome map** identifies host targets of candidalysin
Candidalysin, a cytolytic peptide toxin secreted by the human fungal pathogen Candida albicans, is critical for fungal pathogenesis. Yet, its intracellular targets have not been extensively mapped. Here, we perfo...
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Article
Thiazoloisoindigo-based Polymer Semiconductors: Synthesis, Structure-Property Relationship, Charge Carrier Polarity, and Field-Effect Transistor Performance
Develo** new polymeric semiconductors with excellent device performance is essential for organic electronics. Herein, we synthesized two new thiazoloisoindigo (TzII)-based polymers, namely, P(TzII-dTh-dTh) a...
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Article
Development and validation of a ubiquitin–proteasome system gene signature for prognostic prediction and immune microenvironment evaluation in hepatocellular carcinoma
The ubiquitin proteasome has a major role in the development of many tumors. However, the prognostic importance of ubiquitin proteasome-system genes (UPSGs) in hepatocellular carcinoma (HCC) is not fully defined.
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Article
Development and validation of a vesicle-mediated transport-associated gene signature for predicting prognosis and immune therapy response in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a malignant tumor with a poor prognosis. The progression of numerous malignancies has been linked to abnormal vesicle-mediated transport-related gene (VMTRG) expression. The p...
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Article
A Ratiometric Fluorescence Biosensor for Detection of Alkaline Phosphatase Via an Advanced Chemometric Model
In this paper, a ratiometric fluorescence biosensor was introduced for alkaline phosphatase (ALP) detection based on 2-aminopurine (2-Amp) and thioflavin T (ThT)-G-quadruplex system. We designed a special DNA ...
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Article
Rapid detection of EGFR mutation in CTCs based on a double spiral microfluidic chip and the real-time RPA method
Circulating tumor cells (CTCs) are cells shed from primary or metastatic tumors and spread into the peripheral bloodstream. Mutation detection in CTCs can reveal vital genetic information about the tumors and ...
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Article
Effect of ALA-PDT on inhibition of oral precancerous cell growth and its related mechanisms
Early treatment of oral precancerous lesions is considered as a key strategy for in oral carcinogenesis prevention. Increasing evidence has suggested that the transforming growth factor beta (TGF-β) signaling ...
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Article
Thiazole-Flanked Thiazoloisoindigo as a Monomer for Balanced Ambipolar Polymeric Field-effect Transistors
Electron-rich thiophene-flanked thiazoloisoindigo (Th-TzII) has been reported as a building block for ambipolar polymeric field-effect transistors however with preferable hole transport. Here, we report that b...
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Article
Open AccessCorrection to: Galectin-9 promotes a suppressive microenvironment in human cancer by enhancing STING degradation
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Article
Interfacial Improvement of Carbon Fiber/Epoxy Composites by Incorporating Superior and Versatile Multiscale Gradient Modulus Intermediate Layer with Rigid-flexible Hierarchical Structure
In order to enhance the interfacial adhesion of carbon fiber (CF) and polymer matrix, a multiscale gradient modulus intermediate layer with rigid-flexible (GO-PA) hierarchical structure was designed and fabric...
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Article
Open AccessGalectin-9 promotes a suppressive microenvironment in human cancer by enhancing STING degradation
Galectin-9 (Gal-9) is known to enhance the expansion of myeloid-derived suppressor cells (MDSCs) in murine models. Its contribution to the expansion of MDSCs in human malignancies remain to be investigated. We...
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Article
Robust Variable Selection and Estimation in Threshold Regression Model
We combine the robust criterion with the lasso penalty together for the high-dimensional threshold model. It estimates regression coeffcients as well as the threshold parameter robustly that can be resistant t...
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Article
Output feedback stabilizer design of Boolean networks based on network structure
In genetic regulatory networks, a stable configuration can represent the evolutionary behavior of cell death or unregulated growth in genes. We present analytical investigations on output feedback stabilizer d...
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Article
A thienopyridine, CB-20, exerts diuretic activity by inhibiting urea transporters
Urea transporters (UTs) are transmembrane proteins selectively permeable to urea and play an important role in urine concentration. UT-knockout mice exhibit the urea-selective urine-concentrating defect, witho...
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Article
Improvement of Mechanical Stability for Single Unit Recording Based on Skull Cap in Living Chinchilla
Three-point head fixation was constructed to provide mechanical stability for single unit recording (SUR) on vestibular sensory system in living chinchilla previously. However, it is no more qualified to this ...
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Article
Open AccessmiR-324-3p promotes gastric cancer development by activating Smad4-mediated Wnt/beta-catenin signaling pathway
Emerging evidence suggested that miRNAs can function as oncogenes or tumor suppressors by regulating downstream target genes. miR-324-3p has been reported to function in several carcinomas, but its role in gas...
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Article
The F-box family genes as key elements in response to salt, heavy mental, and drought stresses in Medicago truncatula
F-box protein is a subunit of Skp1-Rbx1-Cul1-F-box protein (SCF) complex with typically conserved F-box motifs of approximately 40 amino acids and is one of the largest protein families in eukaryotes. F-box pr...
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Article
Cryopreservation of Fat Tissue and Application in Autologous Fat Graft: In Vitro and In Vivo Study
Absorption of the autologous fat graft results in repeated harvesting procedures. The cost and complications increase with repeated procedures, but cryopreservation is one way to solve the problem. The aim of ...
