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Life Sciences
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Article
The current status of breeding research in Lolium genus
Italian ryegrass (Lolium multiflorum Lam.; IRG), an important Lolium species, is mainly cultivated in South Korea, Japan, China, and used as forage (pastes, hay, silage). Another important species of Lolium are p...
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Identification of a novel cyclomaltodextrinase annotated as a neopullulanase in the genome of Bacillus cereus
Bacillus cereus is a rod-shaped, gram-positive, motile, and β-hemolytic soil bacterium. B. cereus is an opportunistic pathogen, often responsible for human foodborne illness that is caused by ingestion of starchy...
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Open AccessSensitivity to tumor development by TALEN-mediated Trp53 mutant genes in the susceptible FVB/N mice and the resistance C57BL/6 mice
This study was undertaken to compare the sensitivities of mice strains during tumor induction by transcription activator-like effector nucleases (TALEN)-mediated Trp53 mutant gene. Alterations of their tumorig...
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Investigation of the gut microbiome of Apis cerana honeybees from Vietnam
In this study, the gut microbiome of healthy adult honeybees, Apis cerana, was investigated by sequencing the V3 – V4 region in 16S rRNA gene using Illumina Miseq platform.
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Evaluation of Intestinal Epithelial Barrier Function in Inflammatory Bowel Diseases Using Murine Intestinal Organoids
Intestinal organoids have evolved as potential molecular tools that could be used to study host-microbiome interactions, nutrient uptake, and drug screening. Gut epithelial barrier functions play a crucial rol...
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RUNX3 suppresses metastasis and stemness by inhibiting Hedgehog signaling in colorectal cancer
Disabled tumor suppressor genes and hyperactive oncogenes greatly contribute to cell fates during cancer development because of their genetic alterations such as somatic mutations. However, little is known abo...
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Open AccessLow-density lipoprotein cholesterol goal attainment rates in high-risk patients with cardiovascular diseases and diabetes mellitus in Korea: a retrospective cohort study
Real-world evidence of low-density lipoprotein cholesterol (LDL-C) goal attainment rates for Asian patients is deficient. The objective of this study was to assess the status of dyslipidemia management, especi...
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Open AccessCannabidiol promotes apoptosis via regulation of XIAP/Smac in gastric cancer
According to recent studies, Cannabidiol (CBD), one of the main components of Cannabis sativa, has anticancer effects in several cancers. However, the exact mechanism of CBD action is not currently understood. He...
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Protective effect of oil extracted from Neophocaena asiaeorientalis against hydgrogen peroxide-induced oxidative stress in HepG2 cells
Although animal fat has been reported to be an effective preventative agent for cardiovascular disease, pancreatitis and diabetes, its protective effects against hepatotoxicity have not been thoroughly investi...
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Karyotype and B chromosome variation in Lilium amabile Palibin
Lilium amabile Palibin (2n = 2x = 24) is an endemic lily species in Korea. B chromosomes are supernumerary chromosomes and the presence of B chromosome in L. amabile was known by previous researches. The current ...
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Thermostable CITase from Thermoanaerobacter thermocopriae shows negative cooperativity
The biochemical properties of a putative thermostable cycloisomaltooligosaccharide (CI) glucanotransferase gene from Thermoanaerobacter thermocopriae were determined using a recombinant protein (TtCITase) express...
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Open AccessRegulation of gastrointestinal hormones during laxative activity of gallotannin-enriched extract isolated from Galla Rhois in loperamide-induced constipation of SD rats
Regulation of gastrointestinal hormones have been reported in animal models for constipation undergoing laxative therapy when administered herbal products. We undertook to investigate whether the laxative acti...
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Open AccessInhibition of endoplasmic reticulum stress in high-fat-diet-induced obese C57BL/6 mice: Efficacy of a novel extract from mulberry (Morus alba) leaves fermented with Cordyceps militaris
A few clues about correlation between endoplasmic reticulum (ER) stress and mulberry (Morus alba) leaves were investigated in only the experimental autoimmune myocarditis and streptozotocin-induced diabetes. To i...
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Open AccessAssociation between MKRN3 and LIN28B polymorphisms and precocious puberty
The present study aimed to investigate the association between MKRN3 and LIN28B gene polymorphisms and precocious puberty in Korean boys and girls.
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Open AccessSuccessful development of squamous cell carcinoma and hyperplasia in RGEN-mediated p27 KO mice after the treatment of DMBA and TPA
To evaluate the carcinogenicity of p27 knockout (KO) mice with RNA-guided endonuclease (RGENs)-mediated p27 mutant exon I gene (IΔ), alterations in the carcinogenic phenotypes including tumor spectrum, tumor s...
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Open AccessDose dependence and durability of the therapeutic effects of Asparagus cochinchinensis fermented extract in an ovalbumin-challenged asthma model
The butanol extract of Asparagus cochinchinensis roots fermented with Weissella cibaria (BAfW) significantly suppressed the inflammatory response induced by lipopolysaccharide (LPS) treatment in RAW264.7 cells. T...
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Comprehensive analysis on the homology, interaction, and miRNA regulators of human deleted in azoospermia proteins: updated evolutionary relationships with primates
In humans, at least four copies of deleted in azoospermia (DAZ) proteins are encoded in close proximity along the euchromatic long arm of the Y chromosome, specifically at azoospermia factor region c. DAZ prot...
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Open AccessErratum to: Comparative study of fertilization rates of C57Bl/6NKorl and C57BL/6N mice obtained from two other sources
One of the authors’ names was misprinted. The author list should be corrected as follows.
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Open AccessCorrelation between laxative effects of uridine and suppression of ER stress in loperamide induced constipated SD rats
A correlation between endoplasmic reticulum (ER) stress and laxative effects was first reported in a constipation model treated with an aqueous extract of Liriope platyphylla (AEtLP) roots. To investigate the cor...
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Open AccessLipolytic effect of novel extracts from mulberry (Morus alba) leaves fermented with Cordyceps militaris in the primary adipocytes derived from SD rats
Mulberry (Morus alba) leaves are known to have therapeutic effects on lipid metabolism including lipogenesis, lipolysis and hyperlipidemia. However, novel compounds with strong lipolytic ability among 27 extracts...
