-
Article
Open AccessRadiomic signatures reveal multiscale intratumor heterogeneity associated with tissue tolerance and survival in re-irradiated nasopharyngeal carcinoma: a multicenter study
Post-radiation nasopharyngeal necrosis (PRNN) is a severe adverse event following re-radiotherapy for patients with locally recurrent nasopharyngeal carcinoma (LRNPC) and associated with decreased survival. Bi...
-
Article
Open AccessASCL2 induces an immune excluded microenvironment by activating cancer-associated fibroblasts in microsatellite stable colorectal cancer
Proficient mismatch repair or microsatellite stable (pMMR/MSS) colorectal cancers (CRCs) are vastly outnumbered by deficient mismatch repair or microsatellite instability-high (dMMR/MSI-H) tumors and lack a re...
-
Article
Open AccessThe hTERT-p50 homodimer inhibits PLEKHA7 expression to promote gastric cancer invasion and metastasis
Although accumulating evidence has highlighted the molecular mechanisms by which hTERT promotes tumour cell invasion and metastasis, the molecular mechanisms of the properties enabling hTERT to contribute to i...
-
Article
Open AccessSpatio-temporal evolution and trend prediction of the incidence of Class B notifiable infectious diseases in China: a sample of statistical data from 2007 to 2020
With the accelerated global integration and the impact of climatic, ecological and social environmental changes, China will continue to face the challenge of the outbreak and spread of emerging infectious dise...
-
Article
Open AccessIntegrating single-cell RNA sequencing with spatial transcriptomics reveals immune landscape for interstitial cystitis
Interstitial cystitis (IC) is a severely debilitating and chronic disorder with unclear etiology and pathophysiology, which makes the diagnosis difficult and treatment challenging. To investigate the role of i...
-
Article
Open AccessIrinotecan plus temozolomide in relapsed Ewing sarcoma: an integrated analysis of retrospective studies
The prognosis of patients with relapsed Ewing sarcoma is poor. In this study, we aimed to pooled-analyze the efficacy and safety of the combination of irinotecan and temozolomide in treating patients with rela...
-
Article
Open AccessCorrection to: Galectin-9 promotes a suppressive microenvironment in human cancer by enhancing STING degradation
-
Article
Prolonged SARS-CoV-2 Viral Shedding in Patients with COVID-19 was Associated with Delayed Initiation of Arbidol Treatment and Consulting Doctor Later: A Retrospective Cohort Study
To study data about SARS-CoV-2 virus shedding and clarify the risk factors for prolonged virus shedding.
-
Article
Open AccessGalectin-9 promotes a suppressive microenvironment in human cancer by enhancing STING degradation
Galectin-9 (Gal-9) is known to enhance the expansion of myeloid-derived suppressor cells (MDSCs) in murine models. Its contribution to the expansion of MDSCs in human malignancies remain to be investigated. We...
-
Article
Open AccessThe efficacy and safety of induction chemotherapy combined with concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in nasopharyngeal carcinoma patients: a systematic review and meta-analysis
Induction chemotherapy (IC) combined with concurrent chemoradiotherapy (CCRT) has been recommended as the first-line therapy for locoregional nasopharyngeal carcinoma (NPC). Due to the different chemotherapeut...
-
Article
Open AccessUnbiased screening reveals that blocking exportin 1 overcomes resistance to PI3Kα inhibition in breast cancer
-
Article
Open AccessGenomic and transcriptomic landscapes of Epstein-Barr virus in extranodal natural killer T-cell lymphoma
Extranodal natural killer T-cell lymphoma (nasal type; NKTCL) is an aggressive malignancy strongly associated with Epstein-Barr virus (EBV) infection. However, the role of EBV in NKTCL development is unclear, ...
-
Article
Open AccessAssociations of physical activity and fruit and vegetable intake with well-being and depressive symptoms among obese schoolchildren in Wuhan, China: a cross-sectional study
The prevalence of childhood obesity is increasing and psychological disorder is a common comorbidity of obesity. We investigated the associations of physical activity (PA) and fruit and vegetable (FV) intake w...
-
Article
Open AccessDual-time-point myocardial 18F-FDG imaging in the detection of coronary artery disease
Myocardial 18F-deoxyglucose (18F-FDG) uptake has been observed to be enhanced in patients with coronary artery disease (CAD) under fasting conditions. However, whether the increased 18F-FDG is induced by myocardi...
-
Article
Open AccessEffect of acupuncture treatment on vascular cognitive impairment without dementia: study protocol for a randomized controlled trial
Vascular cognitive impairment, no dementia (VCIND) is a condition at risk for future dementia and should be the target of preventive strategies. Preliminary evidence suggests that acupuncture may be a clinical...
-
Article
Open AccessAcupuncture at local and distal points for chronic shoulder pain: study protocol for a randomized controlled trial
Chronic shoulder pain (CSP) is the third most common type of musculoskeletal pain. It has a major impact on health-related quality of life. In Chinese medicine, CSP is considered one of the conditions most ame...
-
Article
Open AccessClinical features and prognostic factors in patients with bone metastases from hepatocellular carcinoma after liver transplantation
Little is known about the clinical features and prognostic factors of bone metastases of hepatocellular carcinoma (HCC) following liver transplantation (LT).