15 Result(s)
within
Bo Lei
Ophthalmology
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Article
Open AccessAutosomal dominant optic atrophy caused by six novel pathogenic OPA1 variants and genotype–phenotype correlation analysis
To describe the genetic and clinical features of nineteen patients from eleven unrelated Chinese pedigrees with OPA1-related autosomal dominant optic atrophy (ADOA) and define the phenotype-genotype correlations.
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Article
Open AccessDetection of superficial and buried optic disc drusen with swept-source optical coherence tomography
To detect the superficial and buried optic disc drusen (ODD) with swept-source optical coherence tomography (SS-OCT).
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Article
Evaluation of a novel artificial intelligence-based screening system for diabetic retinopathy in community of China: a real-world study
To evaluate the performance of an AI-based diabetic retinopathy (DR) grading model in real-world community clinical setting.
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Article
Open AccessPlasma Ephrin-A1 level in a cohort of diabetic retinopathy patients
To determine plasma ephrin-A1 and VEGF165 levels in a cohort of diabetic retinopathy patients.
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Article
Increase in electroretinogram rod-driven peak frequency of oscillatory potentials and dark-adapted responses in a cohort of myopia patients
To study whether rod- and cone-driven electroretinogram (ERG) responses are altered in myopia patients.
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Chapter
Adeno-Associated Virus (AAV)-Mediated Gene Therapy for Leber Hereditary Optic Neuropathy
Leber hereditary optic neuropathy (LHON) is the first clinically characterized maternally inherited mitochondrial disorder. Up to now, more than 30 pathogenic point mutations in mitochondrial DNA (mtDNA) codin...
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Chapter and Conference Paper
Intravitreal Injection of Amyloid β1–42 Activates the Complement System and Induces Retinal Inflammatory Responses and Malfunction in Mouse
To investigate whether intravitreal injection of amyloid β1–42 (Aβ1–42) activates the complement system and induces retinal inflammatory responses and malfunction, Aβ1–42 was applied intravitreally in mice. Th...
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Article
Open AccessISCEV extended protocol for the photopic On–Off ERG
The International Society for Clinical Electrophysiology of Vision (ISCEV) standard for full-field electroretinography (ERG) describes a minimum procedure, but encourages more extensive testing. This ISCEV ext...
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Chapter
Genetic Background of Uveitis in Chinese Population
Uveitis, known as inflammation of the uvea consisting of the iris, ciliary body, and choroid, is one of the leading causes of blindness in the world. Behcet’s disease (BD), Vogt-Koyanagi-Harada (VKH) syndrome,...
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Chapter
Achromatopsia as a Potential Candidate for Gene Therapy
Achromatopsia is an autosomal recessive retinal disease involving loss of cone function that afflicts approximately 1 in 30,000 individuals. Patients with achromatopsia usually have visual acuities lower than ...
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Chapter
Adeno-Associated Virus Serotype-9 Mediated Retinal Outer Plexiform Layer Transduction is Mainly Through the Photoreceptors
Due to its high ocular transduction, low immune clearance and capability to bypass the brain blood barrier, adeno-associated virus-9 (AAV9) has been regarded as a promising vector for retinal disease gene ther...
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Article
Frequency spectrum and amplitude analysis of dark- and light-adapted oscillatory potentials in albino mouse, rat and rabbit
We studied frequency spectrum, implicit time and amplitude of oscillatory potentials (OPs) in albino mice, rats, and rabbits. Oscillatory potentials were extracted digitally from dark- and light-adapted electr...
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Article
The ERG of guinea pig (Cavis porcellus): comparison with I-type monkey and E-type rat
We have been in search of an alternate species for the monkey to study the effects of drugs on the I-type photopic electroretinogram (ERG) response that is typically seen in the cone-rich retina of the primate...
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Article
Visual evoked cortical potential can be used to differentiate between uncorrected refractive error and macular disorders
The visual evoked cortical potential (VECP) is widely used to verify complaints of reduced visual performance and to identify the site of the disorder. In this study, we investigated the correlation between re...
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Chapter
The Effects of Barium on Retinal Function in the Rabbit
The electroretinogram reflects the light-induced electrical activity in the vertebrate retina. It is highly dependent upon potassium conductances in the neurons of the outer retina. Injecting barium chloride s...
