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Article
Open AccessHuman retinal endothelial cells express functional interleukin-6 receptor
Interleukin (IL)-6 is an inflammatory cytokine present in the eye during non-infectious uveitis, where it contributes to the progression of inflammation. There are two major IL-6 signaling pathways: classic si...
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Article
Open AccessExpression of microRNA in human retinal pigment epithelial cells following infection with Zaire ebolavirus
Survivors of Ebola virus disease (EVD) are at risk of develo** blinding intraocular inflammation—or uveitis—which is associated with retinal pigment epithelial (RPE) scarring and persistence of live Zaire ebola...
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Article
Open AccessICAM-1-related long non-coding RNA: promoter analysis and expression in human retinal endothelial cells
Regulation of intercellular adhesion molecule (ICAM)-1 in retinal endothelial cells is a promising druggable target for retinal vascular diseases. The ICAM-1-related (ICR) long non-coding RNA stabilizes ICAM-1...
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Article
Genome-wide association study for sight-threatening diabetic retinopathy reveals association with genetic variation near the GRB2 gene
Diabetic retinopathy is a serious complication of diabetes mellitus and can lead to blindness. A genetic component, in addition to traditional risk factors, has been well described although strong genetic fact...
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Article
Open AccessPrediction of cis-regulatory elements controlling genes differentially expressed by retinal and choroidal vascular endothelial cells
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Article
Open AccessPrediction of cis-regulatory elements controlling genes differentially expressed by retinal and choroidal vascular endothelial cells
Cultured endothelial cells of the human retina and choroid demonstrate distinct patterns of gene expression. We hypothesized that differential gene expression reflected differences in the interactions of trans...
