32 Result(s)
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Bingyu **g
Life Sciences, general
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Article
E3 ubiquitin ligase TRIM31 alleviates dopaminergic neurodegeneration by promoting proteasomal degradation of VDAC1 in Parkinson’s Disease model
Mitochondrial dysfunction plays a pivotal role in the pathogenesis of Parkinson’s disease (PD). As a mitochondrial governor, voltage-dependent anion channel 1 (VDAC1) is critical for cell survival and death si...
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Article
Open AccessOTUD5 promotes the inflammatory immune response by enhancing MyD88 oligomerization and Myddosome formation
Myddosome is an oligomeric complex required for the transmission of inflammatory signals from TLR/IL1Rs and consists of MyD88 and IRAK family kinases. However, the molecular basis for the self-assemble of Mydd...
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Open AccessInvestigating the causal relationship of gut microbiota with GERD and BE: a bidirectional mendelian randomization
Gut microbiota(GM) have been proven associated with lots of gastrointestinal diseases, but its causal relationship with Gastroesophageal reflux disease(GERD) and Barrett’s esophagus(BE) hasn’t been explored. W...
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Article
Open AccessRNA helicase DDX5 modulates sorafenib sensitivity in hepatocellular carcinoma via the Wnt/β-catenin–ferroptosis axis
Reduced expression of the RNA helicase DDX5 associated with increased hepatocellular carcinoma (HCC) tumor grade and poor patient survival following treatment with sorafenib. While immunotherapy is the first-l...
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Article
Open AccessThe roles of m6A methylation in cervical cancer: functions, molecular mechanisms, and clinical applications
Cervical cancer (CC) is a gynecological neoplasm with the highest incidence rate, primarily attributed to the persistent infection of high-risk Human papillomavirus (HPV). Despite extensive research, the patho...
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Article
Open AccessSmurf1 and Smurf2 mediated polyubiquitination and degradation of RNF220 suppresses Shh-group medulloblastoma
Sonic hedgehog (Shh)-group medulloblastoma (MB) (Shh-MB) encompasses a clinically and molecularly distinct group of cancers originating from the develo** nervous system with aberrant high Shh signaling as a ...
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Article
CD-NTase family member MB21D2 promotes cGAS-mediated antiviral and antitumor immunity
cGAS/DncV-like nucleotidyltransferase (CD-NTase) family members are immune sensors that synthesize diverse nucleotide signals to initiate antiviral response in bacteria and animals. As a founding member of CD-...
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Open AccessKnockdown of METTL16 disrupts learning and memory by reducing the stability of MAT2A mRNA
N6-methyladenosine (m6A) is abundant in the mammalian brain and is considered to have a wide range of effects on learning and memory. Here, we found that the upregulated methyltransferase-like protein 16 (METTL16...
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Article
Open AccessThe role of ZNF143 overexpression in rat liver cell proliferation
Zinc finger protein 143(ZNF143), a member of the Krüppel C2H2-type zinc finger protein family, is strongly associated with cell cycle regulation and cancer development. A recent study suggested that ZNF143 pla...
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Article
The E3 ubiquitin ligase TRIM31 plays a critical role in hypertensive nephropathy by promoting proteasomal degradation of MAP3K7 in the TGF-β1 signaling pathway
Renal fibrosis and inflammation are critical for the initiation and progression of hypertensive renal disease (HRD). However, the signaling mechanisms underlying their induction are poorly understood, and the ...
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Article
TRIM26 positively regulates the inflammatory immune response through K11-linked ubiquitination of TAB1
Protein ubiquitination plays an important role in the regulation of TGF-β-activated kinase 1 (TAK1)-mediated NF-κB activation. It is well established that TAK1 activation is tightly regulated with its binding ...
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Article
Open AccessThe overexpression of Tipe2 in CRC cells suppresses survival while endogenous Tipe2 accelerates AOM/DSS induced-tumor initiation
Aging is a natural and progressive process characterized by an increased frequency of age-related diseases such as cancer. But its mechanism is unclear. TNFAIP8L2 (Tipe2) is an important negative regulator for...
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Article
Open AccessSatb2 regulates the development of dopaminergic neurons in the arcuate nucleus by Dlx1
Dopaminergic (DA) neurons in the arcuate nucleus (ARC) of the hypothalamus play essential roles in the secretion of prolactin and the regulation of energy homeostasis. However, the gene regulatory network resp...
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Article
Production of an epigenetic mutant population of Populus nigra: DNA methylation and phenotype analyses
5-Azacytidine (5-AzaC) causes hypomethylation of genomic DNA and induces phenotype variation in many plant species. Modulating the methylation status of cytosine by 5-AzaC to generate novel phenotypes in popla...
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Article
RNF220 mediates K63-linked polyubiquitination of STAT1 and promotes host defense
STAT1 is a master regulator that orchestrates type 1 and 2 interferon (IFN)-induced IFN-stimulated gene (ISG) expression. The mechanisms by which STAT1 is phosphorylated and activated upon IFN signaling remain...
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Article
Open AccessEmerging role of the Hippo pathway in autophagy
Autophagy is a dynamic circulatory system that occurs in all eukaryotic cells. Cytoplasmic material is transported to lysosomes for degradation and recovery through autophagy. This provides energy and macromol...
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Article
Open AccessSatb2 is required for the regionalization of retrosplenial cortex
The retrosplenial cortex (Rsp) is a transitional cortex located between the neocortex and archicortex, but the molecular mechanism specifying Rsp from the archicortex remains elusive. We here report that the t...
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Article
Open AccessThe poplar pangenome provides insights into the evolutionary history of the genus
The genus Populus comprises a complex amalgam of ancient and modern species that has become a prime model for evolutionary and taxonomic studies. Here we sequenced the genomes of 10 species from five sections of ...
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Article
Open AccessAlcohol-induced autophagy via upregulation of PIASy promotes HCV replication in human hepatoma cells
Both alcohol and hepatitis C virus (HCV) infection could induce cellular autophagy in liver cells, which is considered to be essential for productive HCV replication. However, whether alcohol-induced autophagy...
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Article
A potent Cas9-derived gene activator for plant and mammalian cells
Overexpression of complementary DNA represents the most commonly used gain-of-function approach for interrogating gene functions and for manipulating biological traits. However, this approach is challenging an...
