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Open AccessA streamlined approach for intelligent ship object detection using EL-YOLO algorithm
Maritime objects frequently exhibit low-quality and insufficient feature information, particularly in complex maritime environments characterized by challenges such as small objects, waves, and reflections. Th...
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Open AccessAdverse events reporting of XPO1 inhibitor - selinexor: a real-word analysis from FAERS database
As the world's first oral nuclear export inhibitor, selinexor is increasingly being used in clinical applications for malignant tumors. However, there is no extensive exploration on selinexor's adverse events ...
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Open AccessSolvent-free selective hydrogenation of nitroaromatics to azoxy compounds over Co single atoms decorated on Nb2O5 nanomeshes
The solvent-free selective hydrogenation of nitroaromatics to azoxy compounds is highly important, yet challenging. Herein, we report an efficient strategy to construct individually dispersed Co atoms decorate...
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Open AccessDeep learning model for personalized prediction of positive MRSA culture using time-series electronic health records
Methicillin-resistant Staphylococcus aureus (MRSA) poses significant morbidity and mortality in hospitals. Rapid, accurate risk stratification of MRSA is crucial for optimizing antibiotic therapy. Our study intro...
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Open AccessAuthor Correction: The protein arginine methyltransferase PRMT9 attenuates MAVS activation through arginine methylation
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Open AccessRole of PDLIM1 in hepatic stellate cell activation and liver fibrosis progression
Liver fibrosis is caused by chronic hepatic injury and may lead to cirrhosis, and even hepatocellular carcinoma. When hepatic stellate cells (HSCs) are activated by liver injury, they transdifferentiate into m...
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Open AccessInfralimbic medial prefrontal cortex signalling to calbindin 1 positive neurons in posterior basolateral amygdala suppresses anxiety- and depression-like behaviours
Generalization is a fundamental cognitive ability of organisms to deal with the uncertainty in real-world situations. Excessive fear generalization and impaired reward generalization are closely related to man...
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Open AccessThe protein arginine methyltransferase PRMT9 attenuates MAVS activation through arginine methylation
The signaling adaptor MAVS forms prion-like aggregates to activate the innate antiviral immune response after viral infection. However, spontaneous aggregation of MAVS can lead to autoimmune diseases. The mole...
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Open AccessNear-infrared spectroscopy combined with pattern recognition algorithms to quickly classify raisins
With the development of commodity economy, the emergence of fake and shoddy raisin has seriously harmed the interests of consumers and enterprises. To deal with this problem, a classification method combining ...
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Open AccessRaman spectroscopy combined with machine learning algorithms to detect adulterated Suichang native honey
Zhejiang Suichang native honey, which is included in the list of China’s National Geographical Indication Agricultural Products Protection Project, is very popular. This study proposes a method of Raman spectr...
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Open AccessUSP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS
Activation of MAVS, an adaptor molecule in Rig-I-like receptor (RLR) signaling, is indispensable for antiviral immunity, yet the molecular mechanisms modulating MAVS activation are not completely understood. U...
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Open AccessA study on the characteristics of cognitive function in patients with multiple system atrophy in China
Nonmotor symptoms in patients with multiple system atrophy (MSA) have received an increasing amount of attention in recent years, but no research on MSA patients' cognitive characteristics has been conducted i...
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Open AccessThe tissue specific regulation of miR22 expression in the lung and brain by ribosomal protein L29
Endogenous miR22 is associated with a diverse range of biological processes through post-translational modification of gene expression and its deregulation results in various diseases including cancer. Its exp...
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Open AccessEssential Contribution of Macrophage Tie2 Signalling in a Murine Model of Laser-Induced Choroidal Neovascularization
Wet age-related macular degeneration (AMD), which can cause progressive blindness, is characterised by choroid neovascularization (CNV) in the macular area. Although close attention has been paid to AMD, and a...
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Open Access90-90-90 cascade analysis on reported CLHIV infected by mother-to-child transmission in Guangxi, China: a modeling study
The prevalence of HIV in Guangxi was very high, and there were many children living with HIV (CLHIV) because of larger baseline of pregnant women infected by HIV. It is necessary for children to explore the st...
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Open AccessGenomic regions under selection in the feralization of the dingoes
Dingoes are wild canids living in Australia, originating from domestic dogs. They have lived isolated from both the wild and the domestic ancestor, making them a unique model for studying feralization. Here, w...
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Open AccessNedd4 ubiquitylates VDAC2/3 to suppress erastin-induced ferroptosis in melanoma
Ferroptosis is a newly defined form of regulated cell death characterized by the iron-dependent accumulation of lipid hydroperoxides. Erastin, the ferroptosis activator, binds to voltage-dependent anion channe...
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Open AccessProcessing supramolecular framework for free interconvertible liquid separation
Nanoporous structures constructed by small molecular components exhibited vigorous materials potentials. While maintianing uniform porosity and functional properties, more applicable processing methods for the...
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Quantifying inactive lithium in lithium metal batteries
Lithium metal anodes offer high theoretical capacities (3,860 milliampere-hours per gram)1, but rechargeable batteries built with such anodes suffer from dendrite growth and low Coulombic efficiency (the ratio of...
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Open AccessAn optimal BMI range associated with a lower risk of mortality among HIV-infected adults initiating antiretroviral therapy in Guangxi, China
Previous studies investigating HIV-infected patients suggested a direct link between underweight and the mortality rate of AIDS. However, there was a lack of evidence showing the optimal range of initial body ...