26 Result(s)
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Article
Ecosystem health assessment on the hill and gully area of loess Plateau in Inner Mongolia, China
Maintenance of ecosystem health is the primary focus of a sound ecological restoration. Yet methods involved in quantifying and assessing the health level remain a challenge to the ecological community. In thi...
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Cloning and developmental expression of the Xenopus Nkx6 genes
The evolutionarily conserved Nkx6 family transcription factors play important roles in the patterning of the central nervous system (CNS) and pancreas in vertebrates. In this study, we describe the cloning and ex...
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Xenopus Nkx6.1 and Nkx6.2 are required for mid–hindbrain boundary development
The mid-hindbrain boundary (MHB) organizer is among the best studied local organizers that patterns the midbrain and cerebellum in vertebrates and is established by a regulatory network of several transcriptio...
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Open AccessThe transcriptional network of WRKY53 in cereals links oxidative responses to biotic and abiotic stress inputs
The transcription factor WRKY53 is expressed during biotic and abiotic stress responses in cereals, but little is currently known about its regulation, structure and downstream targets. We sequenced the wheat ort...
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Open AccessA possible role of Drosophila CTCF in mitotic bookmarking and maintaining chromatin domains during the cell cycle
The CCCTC-binding factor (CTCF) is a highly conserved insulator protein that plays various roles in many cellular processes. CTCF is one of the main architecture proteins in higher eukaryotes, and in combinati...
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Overexpression of the novel Zygophyllum xanthoxylum C2H2-type zinc finger gene ZxZF improves drought tolerance in transgenic Arabidopsis and poplar
Zygophyllum xanthoxylum (Bunge) is a perennial woody succulent xerophyte that is one of the most droughttolerant plant species identified to date. In this study, the gene encoding the novel C2H2-type zinc finger ...
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Open AccessExosomes derived from human menstrual blood-derived stem cells alleviate fulminant hepatic failure
Human menstrual blood-derived stem cells (MenSCs) are a novel source of MSCs that provide the advantage of being easy to collect and isolate. Exosomes contain some mRNAs and adhesion molecules that can potenti...
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Open AccessAlcohol-induced autophagy via upregulation of PIASy promotes HCV replication in human hepatoma cells
Both alcohol and hepatitis C virus (HCV) infection could induce cellular autophagy in liver cells, which is considered to be essential for productive HCV replication. However, whether alcohol-induced autophagy...
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Article
Transcriptome analysis of Cd-treated switchgrass root revealed novel transcripts and the importance of HSF/HSP network in switchgrass Cd tolerance
Transcriptome analysis of Cd-treated switchgrass roots not only revealed novel switchgrass transcripts and gene structures but also highlighted the indispensable role of HSF/HSP network in switchgrass Cd toler...
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Open AccessMesenchymal stem cell transplantation ameliorates Sjögren’s syndrome via suppressing IL-12 production by dendritic cells
Mesenchymal stem cells (MSCs) have been demonstrated to be effective in treating autoimmune diseases including Sjögren’s syndrome (SS). We aim to compare the effects of MSC transplantation (MSCT) and the role ...
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Article
Open AccessSatb2 is required for the regionalization of retrosplenial cortex
The retrosplenial cortex (Rsp) is a transitional cortex located between the neocortex and archicortex, but the molecular mechanism specifying Rsp from the archicortex remains elusive. We here report that the t...
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Open AccessEmerging role of the Hippo pathway in autophagy
Autophagy is a dynamic circulatory system that occurs in all eukaryotic cells. Cytoplasmic material is transported to lysosomes for degradation and recovery through autophagy. This provides energy and macromol...
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Article
RNF220 mediates K63-linked polyubiquitination of STAT1 and promotes host defense
STAT1 is a master regulator that orchestrates type 1 and 2 interferon (IFN)-induced IFN-stimulated gene (ISG) expression. The mechanisms by which STAT1 is phosphorylated and activated upon IFN signaling remain...
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Article
Production of an epigenetic mutant population of Populus nigra: DNA methylation and phenotype analyses
5-Azacytidine (5-AzaC) causes hypomethylation of genomic DNA and induces phenotype variation in many plant species. Modulating the methylation status of cytosine by 5-AzaC to generate novel phenotypes in popla...
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Open AccessSatb2 regulates the development of dopaminergic neurons in the arcuate nucleus by Dlx1
Dopaminergic (DA) neurons in the arcuate nucleus (ARC) of the hypothalamus play essential roles in the secretion of prolactin and the regulation of energy homeostasis. However, the gene regulatory network resp...
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Open AccessThe overexpression of Tipe2 in CRC cells suppresses survival while endogenous Tipe2 accelerates AOM/DSS induced-tumor initiation
Aging is a natural and progressive process characterized by an increased frequency of age-related diseases such as cancer. But its mechanism is unclear. TNFAIP8L2 (Tipe2) is an important negative regulator for...
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TRIM26 positively regulates the inflammatory immune response through K11-linked ubiquitination of TAB1
Protein ubiquitination plays an important role in the regulation of TGF-β-activated kinase 1 (TAK1)-mediated NF-κB activation. It is well established that TAK1 activation is tightly regulated with its binding ...
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Open AccessNonwoven-based gelatin/polycaprolactone membrane loaded with ERK inhibitor U0126 for treatment of tendon defects
Tendon is a major component of musculoskeletal system connecting the muscles to the bone. Tendon injuries are very common orthopedics problems leading to impeded motion. Up to now, there still lacks effective ...
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The E3 ubiquitin ligase TRIM31 plays a critical role in hypertensive nephropathy by promoting proteasomal degradation of MAP3K7 in the TGF-β1 signaling pathway
Renal fibrosis and inflammation are critical for the initiation and progression of hypertensive renal disease (HRD). However, the signaling mechanisms underlying their induction are poorly understood, and the ...
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Open AccessKnockdown of METTL16 disrupts learning and memory by reducing the stability of MAT2A mRNA
N6-methyladenosine (m6A) is abundant in the mammalian brain and is considered to have a wide range of effects on learning and memory. Here, we found that the upregulated methyltransferase-like protein 16 (METTL16...
