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Open AccessEfficacy of blinatumomab as maintenance therapy for B-lineage acute lymphoblastic leukemia/lymphoma following allogeneic hematopoietic cell transplantation
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Epiphytic mosses alter Pinus massoniana deadwood microbial and physicochemical properties thereby influencing the decomposition process
Epiphytic mosses play a crucial role in facilitating the decomposition of deadwood and regulating biogeochemical cycling processes in forests. However, the specific impact of epiphytic mosses on the deadwood d...
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Open AccessA one-two punch targeting reactive oxygen species and fibril for rescuing Alzheimer’s disease
Toxic amyloid-beta (Aβ) plaque and harmful inflammation are two leading symptoms of Alzheimer’s disease (AD). However, precise AD therapy is unrealizable due to the lack of dual-targeting therapy function, poo...
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Open AccessRetraction Note: One-step Conjugation of Glycyrrhetinic Acid to Cationic Polymers for High-performance Gene Delivery to Cultured Liver Cell
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Open AccessAuthor Correction: One-step Conjugation of Glycyrrhetinic Acid to Cationic Polymers for High-performance Gene Delivery to Cultured Liver Cell
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Open AccessCancer cell-mitochondria hybrid membrane coated Gboxin loaded nanomedicines for glioblastoma treatment
Glioblastoma (GBM) remains the most lethal malignant tumours. Gboxin, an oxidative phosphorylation inhibitor, specifically restrains GBM growth by inhibiting the activity of F0F1 ATPase complex V. However, its an...
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Open AccessIGFBP5 is an ROR1 ligand promoting glioblastoma invasion via ROR1/HER2-CREB signaling axis
Diffuse infiltration is the main reason for therapeutic resistance and recurrence in glioblastoma (GBM). However, potential targeted therapies for GBM stem-like cell (GSC) which is responsible for GBM invasion...
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Open AccessNear infrared-activatable biomimetic nanogels enabling deep tumor drug penetration inhibit orthotopic glioblastoma
Glioblastoma multiforme (GBM) is one of the most fatal malignancies due to the existence of blood-brain barrier (BBB) and the difficulty to maintain an effective drug accumulation in deep GBM lesions. Here we ...
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Open AccessAddition Pinus massoniana fallen wood improved the growth of Plagiomnium acutum in a substrate cultivation
Soilless culture has been widely used in horticultural plant production, but little research has been done on bryophyte. In this study, we selected a cultivation substrate mixed and proportioned with garden so...
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Reference Work Entry In depth
Preparation and Evaluation of siRNAsome as siRNA and Drug Delivery System
Spherical nucleic acids (SNA) show great potential for gene regulation. However, lack of suitable SNA nanostructure to codeliver small interfering RNA (siRNA) and chemotherapeutic drug to treat cancer is still...
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Open AccessIn vivo Validation of Bimolecular Fluorescence Complementation (BiFC) to Investigate Aggregate Formation in Amyotrophic Lateral Sclerosis (ALS)
Amyotrophic lateral sclerosis (ALS) is a form of motor neuron disease (MND) that is characterized by the progressive loss of motor neurons within the spinal cord, brainstem, and motor cortex. Although ALS clin...
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Open AccessCapturing functional two-dimensional nanosheets from sandwich-structure vermiculite for cancer theranostics
Clay-based nanomaterials, especially 2:1 aluminosilicates such as vermiculite, biotite, and illite, have demonstrated great potential in various fields. However, their characteristic sandwiched structures and ...
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Open AccessNanorods with multidimensional optical information beyond the diffraction limit
Precise design and fabrication of heterogeneous nanostructures will enable nanoscale devices to integrate multiple desirable functionalities. But due to the diffraction limit (~200 nm), the optical uniformity ...
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Open AccessARS2/MAGL signaling in glioblastoma stem cells promotes self-renewal and M2-like polarization of tumor-associated macrophages
The interplay between glioblastoma stem cells (GSCs) and tumor-associated macrophages (TAMs) promotes progression of glioblastoma multiforme (GBM). However, the detailed molecular mechanisms underlying the rel...
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Open AccessActive DNA unwinding and transport by a membrane-adapted helicase nanopore
Nanoscale transport through nanopores and live-cell membranes plays a vital role in both key biological processes as well as biosensing and DNA sequencing. Active translocation of DNA through these nanopores u...
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Using proteomics to identify ubiquitin ligase–substrate pairs: how novel methods may unveil therapeutic targets for neurodegenerative diseases
Ubiquitin ligases play an integral role in fine-tuning signaling cascades necessary for normal cell function. Aberrant regulation of ubiquitin ligases has been implicated in several neurodegenerative diseases,...
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Protocol
Upconversion Nanoparticle-Based Strategy for Crossing the Blood-Brain Barrier to Treat the Central Nervous System Disease
The blood-brain barrier (BBB) is a major challenge for the treatment of central nervous system (CNS) diseases. The BBB strictly regulates the movement of molecules into and out of the brain, and therefore prot...
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The Strategies of Nanomaterials for Traversing Blood-Brain Barrier
Central nervous system (CNS) ailments establish an arrangement of difficult neurotic conditions concerning identification and therapeutics. For the more significant part of these clusters, there is an absence ...
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Large-area gold nanohole arrays fabricated by one-step method for surface plasmon resonance biochemical sensing
Surface plasmon resonance (SPR) nanosensors based on metallic nanohole arrays have been widely reported to detect binding interactions in biological specimens. A simple and effective method for constructing na...
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Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are fatal neurodegenerative disorders that have common molecular and pathogenic characteristics, such as aberrant accumulation and ubiquity...
