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    Article

    Glycyrrhizin Prevents Hemorrhagic Transformation and Improves Neurological Outcome in Ischemic Stroke with Delayed Thrombolysis Through Targeting Peroxynitrite-Mediated HMGB1 Signaling

    Peroxynitrite (ONOO−) and high mobility group box 1 protein (HMGB1) are important cytotoxic factors contributing to cerebral ischemia-reperfusion injury. However, the roles of ONOO− in mediating HMGB1 expression ...

    Hansen Chen, Binghe Guan, Bin Wang, Haiwei Pu, **aoyu Bai… in Translational Stroke Research (2020)

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    Article

    Baicalin Attenuates Blood-Brain Barrier Disruption and Hemorrhagic Transformation and Improves Neurological Outcome in Ischemic Stroke Rats with Delayed t-PA Treatment: Involvement of ONOO−-MMP-9 Pathway

    Tissue plasminogen activator (t-PA) has a restrictive therapeutic window within 4.5 h after ischemic stroke with the risk of hemorrhagic transformation (HT) and neurotoxicity when it is used beyond the time wi...

    Hansen Chen, Binghe Guan, ** Chen, **ngmiao Chen… in Translational Stroke Research (2018)

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    Article

    Inhibition of Peroxynitrite-Induced Mitophagy Activation Attenuates Cerebral Ischemia-Reperfusion Injury

    Activated autophagy/mitophagy has been intensively observed in ischemic brain, but its roles remain controversial. Peroxynitrite (ONOO−), as a representative of reactive nitrogen species, is considered as a criti...

    **ghan Feng, **ngmiao Chen, Binghe Guan, Caiming Li, **hua Qiu… in Molecular Neurobiology (2018)

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    Article

    Whether Metal Element-Containing Herbal Formula Angong Niuhuang Pill Is Safe for Acute Brain Disorders?

    “Angong Niuhuang Pill” (AGNH Pill) has been used as patented herbal formula for treatment of acute brain disorders including ischemic stroke, hemorrhage stroke, and trauma brain injury in traditional Chinese m...

    Lei Zhao, Fu Peng, Binghe Guan, **a Li, Wei Wu… in Biological Trace Element Research (2015)