8 Result(s)

Article

CombPDX: a unified statistical framework for evaluating drug synergism in patient-derived xenografts

Anticancer combination therapy has been developed to increase efficacy by enhancing synergy. Patient-derived xenografts (PDXs) have emerged as reliable preclinical models to develop effective treatments in tra...

Licai Huang, **g Wang, Bingliang Fang, Funda Meric-Bernstam… in Scientific Reports (2022)

Article

Combined MEK/MDM2 inhibition demonstrates antitumor efficacy in TP53 wild-type thyroid and colorectal cancers with MAPK alterations

Most tumors with activating MAPK (mitogen-activated protein kinase) pathway alterations respond poorly to MEK inhibitors alone. Here, we evaluated combination therapy with MEK inhibitor selumetinib and MDM2 in...

Seyed Pairawan, Argun Akcakanat, Scott Kopetz, Coya Tapia… in Scientific Reports (2022)

Article

Author Correction: Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidates for targeted treatment

Hua Sun, Song Cao, R. Jay Mashl, Chia-Kuei Mo, Simone Zaccaria… in Nature Communications (2022)

Article

Structure-based classification predicts drug response in EGFR-mutant NSCLC

Epidermal growth factor receptor (EGFR) mutations typically occur in exons 18–21 and are established driver mutations in non-small cell lung cancer (NSCLC)^1–3. Targeted therapies are approved for patients with ‘c...

Jacqulyne P. Robichaux, **uning Le, R. S. K. Vijayan, J. Kevin Hicks, Simon Heeke… in Nature (2021)

Article

Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidates for targeted treatment

Development of candidate cancer treatments is a resource-intensive process, with the research community continuing to investigate options beyond static genomic characterization. Toward this goal, we have estab...

Hua Sun, Song Cao, R. Jay Mashl, Chia-Kuei Mo, Simone Zaccaria… in Nature Communications (2021)

Article

Author Correction: DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer

Chao Mao, **aoguang Liu, Yilei Zhang, Guang Lei, Yuelong Yan, Hyemin Lee… in Nature (2021)

Article

mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation

Glutathione peroxidase 4 (GPX4) utilizes glutathione (GSH) to detoxify lipid peroxidation and plays an essential role in inhibiting ferroptosis. As a selenoprotein, GPX4 protein synthesis is highly inefficient...

Yilei Zhang, Robert V. Swanda, Litong Nie, **aoguang Liu… in Nature Communications (2021)

Article

TUSC2(FUS1)-erlotinib Induced Vulnerabilities in Epidermal Growth Factor Receptor(EGFR) Wildtype Non-small Cell Lung Cancer(NSCLC) Targeted by the Repurposed Drug Auranofin

Expression of the TUSC2/FUS1 tumor suppressor gene in TUSC2 deficient EGFR wildtype lung cancer cells increased sensitivity to erlotinib. Microarray mRNA expression analysis of TUSC2 inducible lung cancer cell...

Cao **aobo, Mourad Majidi, Meng Feng, Ru** Shao, **g Wang… in Scientific Reports (2016)