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Correction: Empaglifozin improves kidney senescence induced by d-galactose by reducing sirt1-mediated oxidative stress
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Article
Numerical and Experimental Research on Diffusion Characteristic of Polymer Slurry in Narrow Slot at Constant Pressure
To determine the diffusion behavior of a polymer slurry in a narrow slot under a constant pressure head, a relevant simulation model was established based on the theory of a time-varying viscosity, and a visua...
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Open AccessLaser therapy for treating cleft lip or/and palate scarring—a systematic review and meta-analysis
This review aims to assess the efficacy and safety of laser therapy in managing scars resulting from cleft lip and/or palate (CL/P) repair surgeries, as well as to determine the optimal timing for intervention...
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Open AccessChemotherapy-induced high expression of IL23A enhances efficacy of anti-PD-1 therapy in TNBC by co-activating the PI3K-AKT signaling pathway of CTLs
Treatment of advanced triple-negative breast cancer (TNBC) is a great challenge in clinical practice. The immune checkpoints are a category of immunosuppressive molecules that cancer could hijack and impede an...
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Open AccessMicrobial imbalance in Chinese children with diarrhea or constipation
Diarrhea and constipation are common health concerns in children. Numerous studies have identified strong association between gut microbiota and digestive-related diseases. But little is known about the gut mi...
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Article
Open AccessUniversal Murray’s law for optimised fluid transport in synthetic structures
Materials following Murray’s law are of significant interest due to their unique porous structure and optimal mass transfer ability. However, it is challenging to construct such biomimetic hierarchical channel...
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Green Synthesis of Zinc Oxide Nanoparticles Using Aloe vera Leaf Extract and Evaluation of the Antimicrobial and Antioxidant Properties of the ZnO/Regenerated Cellulose Film
The utilization of plant extracts in the synthesis of zinc oxide nanoparticles is recognized as one of the most environmentally friendly approaches. This study focuses on the green synthesis of zinc oxide nano...
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Open AccessUnravelling and reconstructing the biosynthetic pathway of bergenin
Bergenin, a rare C-glycoside of 4-O-methyl gallic acid with pharmacological properties of antitussive and expectorant, is widely used in clinics to treat chronic tracheitis in China. However, its low abundance in...
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Article
Open AccessTwo orthogonal differentiation gradients locally coordinate fruit morphogenesis
Morphogenesis requires the coordination of cellular behaviors along developmental axes. In plants, gradients of growth and differentiation are typically established along a single longitudinal primordium axis ...
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Flexible regenerated cellulose composite films with sandwich structures for high-performance electromagnetic interference shielding
Electromagnetic radiation pollution has become increasingly serious in the electronic, industrial, civil, and military fields. Lightweight, flexible, and high-performance electromagnetic shielding films have r...
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Open AccessThe associations between peripheral inflammatory and lipid parameters, white matter hyperintensity, and cognitive function in patients with non-disabling ischemic cerebrovascular events
The global prevalence of VCI has increased steadily in recent years, but diagnostic biomarkers for VCI in patients with non-disabling ischemic cerebrovascular incidents (NICE) remain indefinite. The primary ob...
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Article
Open AccessGender differences in non-alcoholic fatty liver disease in obese children and adolescents: a large cross-sectional study
Previous studies have reported sex differences in non-alcoholic fatty liver disease (NAFLD) among adults; however, little is known about its occurrence in children and adolescents. This study aims to examine t...
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Open AccessThe P2Y1 receptor in the colonic myenteric plexus of rats and its correlation with opioid-induced constipation
This study was designed to explore the expression changes of P2Y1 receptors in the distal colonic myenteric layer of rats. An opioid induced constipation(OIC) rat model was generated by intraperitoneal (i.p) inje...
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The relative contributions of soft tissue mass components as risk or protective factors of non-alcoholic fatty liver disease in children
Several body components are known to be associated with non-alcoholic fatty liver disease (NAFLD) in children. However, the relative contributions of soft tissue mass components as risk or protective factors o...
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Article
Empagliflozin improves kidney senescence induced by d-galactose by reducing sirt1-mediated oxidative stress
Sodium-glucose cotransporter-2 (SGLT-2) inhibitors have received widespread attention because of their significant protective effects on the kidney. Previous studies have shown that Sirt1, as which is an antia...
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Article
Open AccessFibroblast diversity and plasticity in the tumor microenvironment: roles in immunity and relevant therapies
Cancer-associated fibroblasts (CAFs), enriched in the tumor stroma, have received increasing attention because of their multifaceted effects on tumorigenesis, development, metastasis, and treatment resistance ...
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Article
Open AccessLifestyle patterns influence the composition of the gut microbiome in a healthy Chinese population
High-throughput sequencing allows for the comprehensive analysis of the human intestinal microbiota. However, extensive association analyses between the microbiome and lifestyle differences in the Chinese popu...
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Article
Inelastic Analysis and Damage Assessment of Hydraulic Arched Tunnels in Different Near-Fault Regions
The seismic natural hazard event is a threat of unpredictable events, which can easily cause incalculable damage to hydraulic tunnels. Traditionally, it is necessary to introduce as-recorded ground motions (GM...
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Article
Ultra-stretchable hydrogel thermocouples for intelligent wearables
Stretchable temperature sensors are necessary to enable tactile interaction and thermoregulation in the human body and soft robots. These sensors should be conformably adhered to a deformable surface and maint...
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Numerical and practical investigation of the multiple hole grouting repair law of underground drainage pipeline defects
The grouting sequence and spatial layout of grouting holes are key technical problems in the treatment of underground drainage pipeline defects. An unreasonable grouting parameter design will lead to slurry ru...
